Fetal bovine serum (FBS) for specialized applications
We maintain a large selection of serum products designed for specialty applications and sensitive cell culture, including stem cell research, cancer research, reporter assays, immunoassays, and more.
Why Specialty FBS is important:
 Removes unwanted components |
 Speeds up your workflow |
 Reduces background noise |
 Proven to work with demanding cells |
 Enables more control in your research |
 Delivers consistency |
Choose the specialty serum products for your applications
Tet-System Approved FBS
Description
- Functionally tested to provide researchers with optimal control over their gene expression systems, thus minimizing challenges that can be posed by this type of reagent.
- Delivers a quicker workflow, reduced background noise, more control and consistency.
Ideal for researchers studying…
- Neuroscience
- Cancer research
- Drug screening
- Vaccine development
- Gene editing
Charcoal Stripped FBS
Description
- Reduced lot-to-lot variability on hormone levels, which helps eliminate some of the influences steroids and other components have on cells
- Growth assay using vero cells
Ideal for researchers studying...*
- Hormones or hormone receptors (androgens, estrogens, progesterone)
- Cytotoxic drug response
- Cellular signaling and reporter assays
- Prostate cancer
- Cell cycle
- Tumor cells (breast and bladder)
Publications
- Kuo MT et. al (2020). Collaboration between RSK-EphA2 and gas6-AxL RTK signaling in Arginine starvation response that confers resistance to EGFR receptors.
- Chen ye. Et al (2019). Upregulation of erythropoietin and erythropoietin receptor in castration-resistant progression of prostate cancer
- Murayama N. et al (2017). Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.
- Otsuka T. et al (2013). Suppression of metallothionein 3 gene expression by androgen in LNCaP prostate cancer cells.
- Sekine Y. et al (2010). High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent mechanism.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
Ultra-low lgG FBS
Description
- IgG levels are less than 5 μg/mL; BVD antibody titer is low and not detectable
Ideal for researchers studying...*
- Antibodies
- Viruses and viral response
- Cell-surface epitopes
- IgG dependent cell cytotoxicity
- Ligand-receptor studies
Publications
- Ilja Ritamo et. al (2014). Comparison of the glycosylation of in vitro generated polyclonal human IgG and therapeutic immunoglobulins.
- J S Park et. al (2004). Comparative analysis of the 5’-untranslated region of bovine viral diarrhea virus isolated in Korea.
- Marie Joelle de Gradmont et. al (2003). Intravenous immunoglobulins induce the in-vitro differentiation of human B lymphocytes and the secretion of IgG.
- M Vercammen et. al (1999). Opsonization of Taxoplasma gondii tachyzoites with nonspecific immunoglobulins promotes their phagocytosis by macrophages and inhibits their proliferation in nonphagocytic cells in tissue culture.
- H Watier et. al (1996). Human NK-cell mediated direct and IgG-dependent cytotoxicity against xenogeneic porcine endothelial cells.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
Dialyzed FBS
Description
- Dialyzed by tangential flow filtration utilizing 10,000 MW cutoff filters
- Performance tested for cloning and plating efficiency
Ideal for researchers studying...*
- Proteomics like mass spectrometry
- Mitochondrial function
- Glucose/amino acid deprivation studies
- Isotope labeling
- Cellular signaling and reporter assays
Publications
- Rui tang et. al (2020). Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation.
- Taisuke Hoshi et. al (2019). Lenvatinib induces death of hepatocellular carcinoma cells harboring an activated EGF signaling pathway signaling pathway through inhibition of FGFR-MAPK cascades.
- Ericka Moreno-Mendez et. al (2019). Effect of Biotin supplementation on fatty acid metabolic pathways in 3T3-L1 adipocytes
- Venkata Yenugonda et. al (2017). A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma.
- Abhishek Mandal et.al (2017). L-Arginine uptake by cationic amino acid transporter promotes intra-macrophage survival of Leishmania donovani by enhancing Arginase mediated polyamine synthesis.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
ES Cell-Qualified FBS
Description
- Specially tested for the ability to sustain undifferentiated ES cells while maintaining karyotype integrity, LIF responsiveness, and pluripotency markers
- New improved screening with germ line–competent PRX129/X1 mESC line using a predictive assay that measures plating efficiency and pluripotency maintenance
- High consistency between lots with proven applications in iPSC generation and PSC culture
Ideal for researchers studying...*
- Hormones or hormone receptors (androgens, estrogens, progesterone)
- Induced pluripotent stem cells (iPSCs)
- Cellular reprogramming
- Embryonic stem cells (ESCs)
- Embryonic development
Publications
- Paola Rebuzzini et. al (2020). Chronic cypermethrin exposure alters mouse embyronic stem cells growth kinetics, induces Phase II detoxification response and affects pluripotency and differentiation gene expression.
- Minsuh Kim et. al (2019). Patient derived lung cancer organoids as in vitro cancer models for therapeutic screening.
- Neda Eskandari et. al (2018). The combination of retinoic acid and estrogen can increase germ cells gene expression in mouse embryonic stem cells derived primordial germ cells.
- Rong Hu et. al (2017). Transplantation of donor-origin mouse embryonic stem cell-derived thymic epithelial progenitors prevents the development of chronic graft-versus-host disease in mice.
- Dasa Bohaciakova et. al (2017). An efficient method of generation of knockout human embryonic stem cells using CRISPR/Cas9 system.
- Stephen P Jenkinson et. al (2017). Embryonic stem cell-derived neurons grown on multi-electrode arrays as a novel in-vitro bioassay for the detection of Clostridium botulinum neurotoxins.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
MSC Qualified FBS
Description
- Performance-tested using standard 14-day MSC CFU-F assay
- Each lot is tested against an in-house FBS reference standard using cells from a master cell bank of MSCs from normal bone marrow donors, which helps ensure lot-to-lot consistency
Ideal for researchers studying...*
- Mesenchymal stem cells
- Mesenchymal stromal cells
- Osteogenesis
- Chondrogenesis and cartilage
- Collagen and other extracellular matrices (ECM)
- Adipose tissue and adipogenesis
Publications
- Sabrina Viau et.al (2019). A highly standardized and characterized human platelet lysate for efficient and reproducible expansion of human bone marrow mesenchymal stromal cells.
- A Srivastava et. al (2018). Secretome of differentiated PC12 cells enhances neuronal differentiation in human mesenchymal stem cells via NGF-like mechanism.
- Ganesh Swaminathan et. al (2018). Phenotype-based selection of bone marrow mesenchymal stem cell-derived smooth muscle cells for elastic matrix regenerative in abdominal aortic aneurysms.
- Nebiyyeh Kamaci et. al (2011). Selective silencing of DNA Topoisomerase Iiβ in human mesenchymal stem cells by siRNAs (small interfering RNAs)
- Thomas G Koch et. al (2009). Improved isolation protocol for Equine cord-blood derived mesenchymal stromal cells.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
Exosome-Depleted FBS
Description
- ≥90% of exosomes depleted
- Complex manufacturing process that retains the nutrients your cells need
- Full quality testing for sterility, mycoplasmas, performance, and endotoxins
Ideal for researchers studying...*
- Exosomes and extracellular vesicles
- MicroRNA
- Cell-cell communication
Publications
- Eduarda M Guerriero et. al (2019). Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration and size exclusion chromatography.
- Yanting Hu et. al (2019). Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer.
- Jose Manuel Reyes-Ruiz et. al (2019). Isolation and characterization of exosomes released from mosquito cells infected with dengue virus.
- Marisa N Madison et; al (2017). Isolation of exosomes from semen for in-vitro uptake and HIV-1 infection assays.
- Kaloyan Takov et. al (2017). Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
Tet-System Approved FBS
Description
- Functionally tested to provide researchers with optimal control over their gene expression systems, thus minimizing challenges that can be posed by this type of reagent.
- Delivers a quicker workflow, reduced background noise, more control and consistency.
Ideal for researchers studying…
- Neuroscience
- Cancer research
- Drug screening
- Vaccine development
- Gene editing
Charcoal Stripped FBS
Description
- Reduced lot-to-lot variability on hormone levels, which helps eliminate some of the influences steroids and other components have on cells
- Growth assay using vero cells
Ideal for researchers studying...*
- Hormones or hormone receptors (androgens, estrogens, progesterone)
- Cytotoxic drug response
- Cellular signaling and reporter assays
- Prostate cancer
- Cell cycle
- Tumor cells (breast and bladder)
Publications
- Kuo MT et. al (2020). Collaboration between RSK-EphA2 and gas6-AxL RTK signaling in Arginine starvation response that confers resistance to EGFR receptors.
- Chen ye. Et al (2019). Upregulation of erythropoietin and erythropoietin receptor in castration-resistant progression of prostate cancer
- Murayama N. et al (2017). Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.
- Otsuka T. et al (2013). Suppression of metallothionein 3 gene expression by androgen in LNCaP prostate cancer cells.
- Sekine Y. et al (2010). High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent mechanism.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
Ultra-low lgG FBS
Description
- IgG levels are less than 5 μg/mL; BVD antibody titer is low and not detectable
Ideal for researchers studying...*
- Antibodies
- Viruses and viral response
- Cell-surface epitopes
- IgG dependent cell cytotoxicity
- Ligand-receptor studies
Publications
- Ilja Ritamo et. al (2014). Comparison of the glycosylation of in vitro generated polyclonal human IgG and therapeutic immunoglobulins.
- J S Park et. al (2004). Comparative analysis of the 5’-untranslated region of bovine viral diarrhea virus isolated in Korea.
- Marie Joelle de Gradmont et. al (2003). Intravenous immunoglobulins induce the in-vitro differentiation of human B lymphocytes and the secretion of IgG.
- M Vercammen et. al (1999). Opsonization of Taxoplasma gondii tachyzoites with nonspecific immunoglobulins promotes their phagocytosis by macrophages and inhibits their proliferation in nonphagocytic cells in tissue culture.
- H Watier et. al (1996). Human NK-cell mediated direct and IgG-dependent cytotoxicity against xenogeneic porcine endothelial cells.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
Dialyzed FBS
Description
- Dialyzed by tangential flow filtration utilizing 10,000 MW cutoff filters
- Performance tested for cloning and plating efficiency
Ideal for researchers studying...*
- Proteomics like mass spectrometry
- Mitochondrial function
- Glucose/amino acid deprivation studies
- Isotope labeling
- Cellular signaling and reporter assays
Publications
- Rui tang et. al (2020). Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation.
- Taisuke Hoshi et. al (2019). Lenvatinib induces death of hepatocellular carcinoma cells harboring an activated EGF signaling pathway signaling pathway through inhibition of FGFR-MAPK cascades.
- Ericka Moreno-Mendez et. al (2019). Effect of Biotin supplementation on fatty acid metabolic pathways in 3T3-L1 adipocytes
- Venkata Yenugonda et. al (2017). A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma.
- Abhishek Mandal et.al (2017). L-Arginine uptake by cationic amino acid transporter promotes intra-macrophage survival of Leishmania donovani by enhancing Arginase mediated polyamine synthesis.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
ES Cell-Qualified FBS
Description
- Specially tested for the ability to sustain undifferentiated ES cells while maintaining karyotype integrity, LIF responsiveness, and pluripotency markers
- New improved screening with germ line–competent PRX129/X1 mESC line using a predictive assay that measures plating efficiency and pluripotency maintenance
- High consistency between lots with proven applications in iPSC generation and PSC culture
Ideal for researchers studying...*
- Hormones or hormone receptors (androgens, estrogens, progesterone)
- Induced pluripotent stem cells (iPSCs)
- Cellular reprogramming
- Embryonic stem cells (ESCs)
- Embryonic development
Publications
- Paola Rebuzzini et. al (2020). Chronic cypermethrin exposure alters mouse embyronic stem cells growth kinetics, induces Phase II detoxification response and affects pluripotency and differentiation gene expression.
- Minsuh Kim et. al (2019). Patient derived lung cancer organoids as in vitro cancer models for therapeutic screening.
- Neda Eskandari et. al (2018). The combination of retinoic acid and estrogen can increase germ cells gene expression in mouse embryonic stem cells derived primordial germ cells.
- Rong Hu et. al (2017). Transplantation of donor-origin mouse embryonic stem cell-derived thymic epithelial progenitors prevents the development of chronic graft-versus-host disease in mice.
- Dasa Bohaciakova et. al (2017). An efficient method of generation of knockout human embryonic stem cells using CRISPR/Cas9 system.
- Stephen P Jenkinson et. al (2017). Embryonic stem cell-derived neurons grown on multi-electrode arrays as a novel in-vitro bioassay for the detection of Clostridium botulinum neurotoxins.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
MSC Qualified FBS
Description
- Performance-tested using standard 14-day MSC CFU-F assay
- Each lot is tested against an in-house FBS reference standard using cells from a master cell bank of MSCs from normal bone marrow donors, which helps ensure lot-to-lot consistency
Ideal for researchers studying...*
- Mesenchymal stem cells
- Mesenchymal stromal cells
- Osteogenesis
- Chondrogenesis and cartilage
- Collagen and other extracellular matrices (ECM)
- Adipose tissue and adipogenesis
Publications
- Sabrina Viau et.al (2019). A highly standardized and characterized human platelet lysate for efficient and reproducible expansion of human bone marrow mesenchymal stromal cells.
- A Srivastava et. al (2018). Secretome of differentiated PC12 cells enhances neuronal differentiation in human mesenchymal stem cells via NGF-like mechanism.
- Ganesh Swaminathan et. al (2018). Phenotype-based selection of bone marrow mesenchymal stem cell-derived smooth muscle cells for elastic matrix regenerative in abdominal aortic aneurysms.
- Nebiyyeh Kamaci et. al (2011). Selective silencing of DNA Topoisomerase Iiβ in human mesenchymal stem cells by siRNAs (small interfering RNAs)
- Thomas G Koch et. al (2009). Improved isolation protocol for Equine cord-blood derived mesenchymal stromal cells.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
Exosome-Depleted FBS
Description
- ≥90% of exosomes depleted
- Complex manufacturing process that retains the nutrients your cells need
- Full quality testing for sterility, mycoplasmas, performance, and endotoxins
Ideal for researchers studying...*
- Exosomes and extracellular vesicles
- MicroRNA
- Cell-cell communication
Publications
- Eduarda M Guerriero et. al (2019). Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration and size exclusion chromatography.
- Yanting Hu et. al (2019). Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer.
- Jose Manuel Reyes-Ruiz et. al (2019). Isolation and characterization of exosomes released from mosquito cells infected with dengue virus.
- Marisa N Madison et; al (2017). Isolation of exosomes from semen for in-vitro uptake and HIV-1 infection assays.
- Kaloyan Takov et. al (2017). Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes.
* These results are based on a review of approximately 10,000 publications using query terms based on the six specialty FBS products offered by Thermo Fisher Scientific. These terms were generated by the MeSH (medical subject headings) taxonomy based on the full text of the paper.
For research use or further manufacturing use only. Serum and blood proteins are not for direct administration into humans or animals.
