Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) is involved in many biological responses including the growth and development of granulocyte and macrophage progenitor cells, stimulation and the initiation of differentiation of myeloblasts and monoblasts, and chemotaxis of eosinophils.
Human Interleukin 2 (IL2) causes proliferation of T-cells and is a central regulator of immune responses. IL2 stimulates the growth and differentiation of B cells, natural killer (NK) cells, lymphocyte activated killer (LAK) cells, monocytes/macrophages and oligodendrocytes.
SCF, Stem Cell Factor, is a cytokine that can exist both as a transmembrane protein and a soluble protein, playing an important role in hematopoiesis, spermatogenesis, and melanogenesis. Mutations in SCF or its receptor, c-kit, can result in anemia that may be severe enough to cause death.
IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells, and it can potentiate the antiviral and antitumor affects of the type I interferons.
EGF, Epidermal Growth Factor, acts a potent mitogenic factor that plays an important role in the growth, proliferation and various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Dysregulation of EGF production has been associated with the growth and progression of certain cancers.