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3D cell cultures have great potential in disease modeling, regenerative medicine, and other models. 3D cell cultures, including spheroid and organoid cultures, offer opportunities to better understand complex biology than 2D cell cultures can provide.

2D versus 3D cell cultures

2D cell culture models grown from immortalized cell lines have served as a foundation for disease modeling and drug development for decades. These cell cultures are generally easy to grow and maintain but typically lack biological complexity and physiological relevance.

3D cell cultures are developed to imitate tissue-like or organ-like characteristics that better replicate the cellular environment in vivo than do 2D cell cultures. They exhibit gene and protein expression signatures close to those observed in vivo. 3D cell cultures, such as organoids and spheroids, are now utilized in neurobiology, stem cell research, regenerative medicine, and cancer biology.

While generating in vitro 3D cell cultures can be more challenging, once established they can offer key insights for translational research. With advanced tissue engineering approaches, there has been considerable progression from 2D to 3D cell cultures that is helping provide more physiological relevance to in vitro experiments.

3D cell culture services

Custom Services technician working in clean hood during development of a 3D cell model

Let’s face it, you are in a difficult position: being asked to transition your research to more physiologically relevant models, but the path to generating and interrogating 3D cell culture models is not always obvious. Our cell model services will help extend your capabilities by deploying our dedicated team of cell biology experts to your custom 3D cell model project. We are a team of experienced researchers with access to the latest tools from the brands you trust. We work closely with cell culture and analysis systems experts to help solve your most difficult research problems.

Options include:

  • Cancer spheroid models
  • Primary cell spheroid models
  • Organoid culture models
  • Organotypic models
  • Custom 3D cell culture models

Contact our 3D cell culture scientists

Brightfield image at low magnification of organoids cultured in a 3D hydrogel droplet

3D cell culture educational tools

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3D cell culture protocols & methods

dish with culture and hand

Cancer spheroids and tumoroids

Fluorescent and brightfield overlay image of intestinal organoid

Stem cell and organoid culture

3D neuronal cultures stained with Tubulin Tracker Deep Red

3D neuroscience


FREE 3D Cell Culture eLearning Courses

We are now offering free e-Learns to share our expertise and assist with advancing your research. Follow the links below and start your free learning adventure in the basics of 3D cell culture and then progress to our neural organoid training course.

Getting started in 3D cell culture
Neural organoid generation from PSCs

For Research Use Only. Not for use in diagnostic procedures.