MicroRNAs (miRNAs) are short, highly conserved small noncoding RNA molecules naturally occurring in the genomes of plants and animals. They are 17–27 nucleotides long and regulate posttranscriptional mRNA expression, typically by binding to the 3’ untranslated region (3’-UTR) of the complementary mRNA sequence, resulting in translational repression and gene silencing. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are “master regulators” of many important biological processes.
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Which Invitrogen miRNA Mimic or Inhibitor is right for you?
|Novel design to minimize off-target effects||Next generation chemistries for lowest off-target effects||Chemically modified for good efficacy||Next generation chemistries for highest efficacy|
|Order now||Order now||Order now||Order now|
|Pre-miR Precursors||mirVana miRNA Mimics||Anti-miR Inhibitors||mirVana miRNA Inhibitors|
|Function||Mimic endogenous miRNAs||Mimic endogenous miRNAs||Inhibit endogenous miRNAs||Inhibit endogenous miRNAs|
|Content Database||100% Coverage of miRBase v 15*||100% Coverage of miRBase v 21**||100% Coverage of miRBase v 15*||100% Coverage of miRBase v 21**|
|Model System||In Vitro||In Vitro & In Vivo||In Vitro||In Vitro & In Vivo|
|Species Covered||Human, Mouse & Rat (Other species: use custom tool)||Human, Mouse & Rat (Other species: use custom tool)||Human, Mouse & Rat (Other species: use custom tool)||Human, Mouse & Rat (Other species: use custom tool)|
|Custom Design Tool||Design your custom miRNAs mimics||Design your custom miRNAs mimics||Design your custom miRNA inhibitors||Design your custom miRNA inhibitors|
|miRNA Libraries||Pre-Designed or Custom Libraries||Designed or Custom Libraries||Designed or Custom Libraries||Designed or Custom Libraries|
|Recommended Catalog #||AM17100: Pre-miR miRNA Precursor 5 nM||4464066: mirVana™ miRNA Mimic 5 nM||AM17000: Anti-miR Inhibitor 5 nM||4464084: mirVana™ miRNA Inhibitor 5 nM|
Additional products for miRNA research
miRNAs require special tools for accurate and sensitive analysis. We offer a broad portfolio of products that provides complete solutions for either miRNA expression profiling or a targeted quantitation/target validation.
|miRNA Controls, Customs, & Libraries||miRNA & Small RNA Isolation||Real Time PCR Based miRNA Analysis||miRNA & Non-Coding RNA Microarrays|
miRNA Experimental Planning & Design