LCM Caps

Specially designed for research use with the Arcturus® Laser Capture Microdissection (LCM) instruments, CapSure® HS and CapSure® Macro LCM Caps enable the precise and rapid extraction of pure populations of cells from heterogeneous sample preparations. CapSure® Caps may be used to isolate individual cells or thousands of cells on a single cap.

Key Features

  • Gentle application—nondamaging microdissection preserves the integrity of the captured material
  • Versatile extraction—capture both large and small amounts of cells

Ensure the Integrity of Microdissected Cells for Downstream Molecular Analysis

All CapSure® LCM Caps have a transfer film bonded to the lower cap surface. Using the Arcturus® Microdissection System, an infrared laser pulses through the top of the cap during LCM and interacts with the transfer film, which then melts and bonds to the cells or regions of interest. The film absorbs the laser radiation—instead of the tissue or cell sample—creating a gentle, nondamaging microdissection that preserves the integrity of the captured material.

Extract Large Amounts of Cells with CapSure® Macro LCM Caps

CapSure® Macro LCM Caps provide the maximum area for capturing several thousand cells on a single cap. This is particularly useful for downstream applications that require large numbers of cells to obtain enough material for analysis, such as some protein analysis techniques. The CapSure® Macro LCM Caps fit directly onto 0.5 mL microcentrifuge tubes for extraction of biological molecules from captured cells.

Extract Small Numbers of Cells with High-Sensitivity CapSure® HS Caps

CapSure® HS LCM Caps enable the highly sensitive extraction and detection of biological molecules from small numbers of cells. CapSure® HS LCM Caps contain ridges at the bottom that keep the active capture area of the cap twelve microns off the surface of the sample. This separation ensures the precise capture of up to several hundreds of cells. In addition, the CapSure® LCM Caps work with ExtracSure devices that minimize the dilution of biological molecules extracted from captured cells. This optimizes the recovery of these molecules for downstream molecular analysis.