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Application Title Year
Virus hemocytes Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity. 2019
Mouse striatum Coxiella burnetiiRpoS Regulates Genes Involved in Morphological Differentiation and Intracellular Growth. 2019
Human A498 Expression Levels of microRNAs miR-93 and miR-200a in Pancreatic Adenocarcinoma with Special Reference to Differentiation and Relapse-Free Survival 2019
Mouse cortex Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis 2019
Human MV-4-11 MicroRNA-92a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells 2019
Bacteria pond sediment Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus 2019
Human HCC1954, SKBR3, temporal-lobe tissue Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling 2019
Human BT474 Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor 2019
Human hepatocytes Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease 2018
Human, Mouse, Ovine cytotrophoblast cells, liver, kidney, striatum, plasma Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo 2018
Human breast cancer Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine 2018
Human, Mouse, NHP multiple primary tissues Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo 2018
Non-human primate brain Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection 2018
Rat plasma, serum mRNA treatment produces sustained expression of enzymatically active human ADAMTS13 in mice 2018
Human metastatic clear cell renal cell carcinoma Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin 2018
Mouse, Non-human primate liver, plasma Quantitative Systems Pharmacology Model of hUGT1A1-modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler-Najjar Syndrome Type 1 2018
Bacteria water samples RNAi modulation of placental sFLT1 for the treatment of preeclampsia 2018
Rat plasma, liver Safety Evaluation of Lipid Nanoparticle-Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey 2018
Human HeLa The immune response of Mytilus edulis hemocytes exposed to Vibrio splendidus LGP32 strain: A transcriptomic attempt at identifying molecular actors 2018
Human liver Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier 2018
Non-human primate liver A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors 2017
Non-human primate bone BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors 2017
Non-human primate spleen GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) 2017
Non-human primate aortic branch HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions 2017
Non-human primate skin Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System 2017
Mouse lung Long noncoding RNA HULC modulates the phosphorylation of YB-1 through serving as a scaffold of extracellular signal-regulated kinase and YB-1 to enhance hepatocarcinogenesis 2017
Non-human primate ovary, pancreas Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain 2017
Human hepatocytes The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection 2017
Human A549, liver A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo 2016
Human pancreatic tissue Biliary Elimination of Pemetrexed Is Dependent on Mrp2 in Rats: Potential Mechanism of Variable Response in Nonalcoholic Steatohepatitis 2016
Mouse fallopian tube, fat, heart, intestine Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips 2016
Mouse liver Comparison of the QuantiGene 2.0 Assay and Real-Time RT-PCR in the Detection of p53 Isoform mRNA Expression in Formalin-Fixed Paraffin-Embedded Tissues- A Preliminary Study 2016
Mouse neurons, muscle, pancreas, skin, spleen Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose 2016
Mouse bladder Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300 2016
Mouse thymus Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain 2016
Virus HepG2 Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir 2016
Mouse adrenal gland Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing 2016
Mouse kidney MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients 2016
Human WM-115 The paraffin-embedded RNA metric (PERM) for RNA isolated from formalin-fixed, paraffin-embedded tissue 2016
Mouse heart, brain Therapeutic siRNA for drug-resistant HER2-positive breast cancer 2016
Mouse kidney Transcriptional Profiling of Coxiella burnetii Reveals Extensive Cell Wall Remodeling in the Small Cell Variant Developmental Form 2016
Human MM.1S Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice 2016
Human HDLM-2 VEGF-A mRNA measurement in meningiomas using a new simplified approach: branched DNA and chemiluminescence 2016