High quality gRNAs for any CRISPR application

When using the CRISPR-Cas9 system to knockout gene expression or knock-in a specific mutation, the design, production, and delivery of high quality gRNAs are critical to achieving a successful result. The scientists at Thermo Fisher Scientific  have developed multiple CRISPR gRNA solutions to help you realize your goals and develop high impact models to move your research forward. Whether you need transfection-ready gRNAs for use with Invitrogen TrueCut Cas9 Protein v2 or you need to harness lentivirus to deliver your editing tools to hard to transfect or primary cells, we have you covered. Use our selection guide below to find the right gRNAs for your experiment.

Available CRISPR-Cas9 guide RNA formats

TrueGuide Synthetic gRNA

LentiArray Lentiviral gRNA

Precision gRNA Synthesis Kit
FormatSynthetic RNA oligo, chemically modified for stabilityLentiviral particlesIn vitro-transcribed (IVT) gRNA
ApplicationKnockout (predesigned) or knock-in (custom)Knockout, including library screening Knockout or knock-in

Human and mouse - predesigned 

All species - custom

Human - predesigned

All species - custom

All species
Delivery methodLipid-mediated transfection or electroporationLentiviral transductionLipid-mediated transfection or electroporation
Recommended Cas9 FormatInvitrogen TrueCut Cas9 Protein v2Invitrogen LentiArray Cas9 LentivirusInvitrogen TrueCut Cas9 Protein v2
ControlsPositive and negative controls availablePositive and negative controls available 
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CRISPR Controls

High-quality controls play an integral role in the successful development and performance of high-throughput screens. Don't forget to include controls to help you optimize delivery conditions, maximize editing efficiency, and establish hit selection criteria. Learn more

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