The Genome Editing Resource Library provides you access to different educational and technical learning materials, including webinars, videos, application notes, validated protocols, scientific posters, and publications.

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TypeNameGenome editing technology
Application noteA rapid method for GFP tagging of genes and enrichment of edited cells CRISPR
Application noteAchieve high specificity and on-target efficiency with TrueCut HiFi Cas9 Protein   CRISPR
Application noteAdvancing CAR T cell therapy with CTS TrueCut Cas9 ProteinCRISPR
Application noteAnalysis of the performance of GMP-manufactured Cas9 nucleases for cell therapy applicationsCRISPR
Application noteAchieve functional knockout in up to 90% of human primary T cells CRISPR
Application noteDelivery solutions for immune cells  CRISPR
Application noteGene modification for cell therapy applications: Achieving efficiency with CTS TrueCut Cas9 Protein and the CTS Xenon SystemCRISPR
Application noteHow to monitor and minimize off-target events during genome editingCRISPR
Application noteImproving and simplifying the design of knock-in experiments  using the TrueDesign Genome EditorCRISPR, TALEN
Application noteImprove genome editing outcomes in biologically relevant cell modelsCRISPR, TALEN
Application noteKey considerations in genome editing  CRISPR, TALEN
Application notePowerful loss-of-function screening with LentiArray CRISPR gRNAs: maximize knockout efficiency while maintaining specificityCRISPR
Application noteUsing Sanger sequencing to facilitate CRISPR and TALEN-mediated genome editing workflowsCRISPR, TALEN
ArticleCRISPR-generated CAR-T cells: A new frontier in the treatment of solid tumors  CRISPR
ArticleCollaboration and CRISPR tools move scientists closer to a cure for sight loss  CRISPR
ArticleDesign your CRISPR gene editing experiments in as little as five minutes  CRISPR, TALEN
ArticleLooking to overcome challenges in your gene editing workflow?  CRISPR, TALEN
ArticleModeling rare diseases using CRISPR gene editing—Could fruit flies save lives?  CRISPR
ArticleRevolutionizing drug discovery: The role of CRISPR gene editing in target validation  CRISPR
BrochureCRISPR-Cas9 Protein for Genome Editing—Getting Started Guide  CRISPR
BrochureCRISPR Genome Editing Tools  CRISPR
FAQsCRISPR-based genome editing—Getting Started FAQsCRISPR
FAQsCRISPR-based genome editing—Troubleshooting FAQsCRISPR
FAQsTALEN-based genome editing—Getting Started FAQsTALEN
FAQsTALEN-based genome editing—Troubleshooting FAQsTALEN
HandbookGenome Editing Resource GuideCRISPR, TALEN
InterviewCRISPR-Cas9: A transformative tool for treating debilitating genetic diseaseCRISPR
InterviewHow CRISPR provides a unique opportunity to generate rare disease avatarsCRISPR
InfographicCas9 Plasmids vs ProteinsCRISPR
InfographicCRISPR-Cas9 - A promising tool for therapeutics developmentCRISPR
InfographicTips & Tricks for CRISPR SuccessCRISPR
ProtocolCRISPR-Cas9 Genome Editing In Human Induced Pluripotent Stem CellCRISPR
ProtocolCell-Line Specific CRISPR RNP Transfection Conditions Using Lipofectamine CRISPRMAX ReagentCRISPR
ProtocolCell-Line Specific CRISPR RNP Electroporation Conditions Using Neon SystemCRISPR
ProtocolEmbryo Microinjection With CRISPR-Cas9 in Mice and ZebrafishCRISPR
ProtocolGeneral CRISPR RNP Transfection GuidelinesCRISPR
ProtocolGuidelines For Clone Isolation and ValidationCRISPR
ProtocolVerification of CRISPR Gene Editing EfficiencyCRISPR
Publication (2023)High-Efficiency CRISPR/Cas9-Mediated Correction of a Homozygous Mutation in Achromatopsia-Patient-Derived iPSCs  CRISPR
Publication (2023)Target-seq: single workflow for detection of genome integration site, DNA translocation and off-target events  CRISPR, TALEN
Publication (2022)Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL  CRISPR, TALEN
Publication (2020)A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries  CRISPR
Publication (2020)Development of a Proline-Based Selection System for Reliable Genetic Engineering in Chinese Hamster Ovary Cells  CRISPR, TALEN
Publication (2019)Lipofection-mediated genome editing using DNA-free delivery of the Cas9/gRNA ribonucleoprotein into plant cells  CRISPR
Publication (2018)Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting  CRISPR
Publication (2018)TEG-seq: an ion torrent-adapted NGS workflow for in cellulo mapping of CRISPR specificity  CRISPR
Publication (2017)Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA  CRISPR
Publication (2017)Programmable type III-A CRISPR-Cas DNA targeting modules  CRISPR
Publication (2016)Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNACRISPR
Publication (2016)Improved delivery of Cas9 protein/gRNA complexes using lipofectamine CRISPRMAXCRISPR
Publication (2015)Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection.CRISPR
Publication (2015)Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.CRISPR
Publication (2015)Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of NucleaseCRISPR
Publication (2015)Efficient Intracellular Delivery of Native ProteinsCRISPR
Publication (2015)CRISPR/Cas9 nuclease cleavage combined with Gibson assembly for seamless cloning.CRISPR
Publication (2015)Engineered CRISPR-Cas9 nucleases with altered PAM specificitiesCRISPR
Publication (2015)Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancersCRISPR
Publication (2015)Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cellsCRISPR
Publication (2015)In vivo genome editing using Staphylococcus aureus Cas9CRISPR
Publication (2015)Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectorsCRISPR
Publication (2015)Multiplex conditional mutagenesis using transgenic expression of Cas9 and sgRNAsCRISPR
Publication (2015)Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cellsCRISPR
Publication (2015)A Cas9–guide RNA complex preorganized for target DNA recognitionCRISPR
Publication (2014)Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleasesCRISPR
Publication (2014)Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effectsCRISPR
Publication (2014)DNA interrogation by the CRISPR RNA-guided endonuclease Cas9CRISPR
Publication (2014)Programmable RNA recognition and cleavage by CRISPR/Cas9CRISPR
Publication (2014)Landscape of target: guide homology effects on Cas9-mediated cleavageCRISPR
Publication (2014)Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNACRISPR
Publication (2014)Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporterCRISPR
Publication (2014)Crystal structure of Cas9 in complex with guide RNA and target DNACRISPR
Publication (2014)Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo CRISPR
Publication (2014)Guide RNA functional modules direct Cas9 activity and orthogonalityCRISPR
Publication (2014)Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target CleavageCRISPR
Publication (2014)Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding toolCRISPR
Publication (2014)GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleasesCRISPR
Publication (2014)Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational ActivationCRISPR
Publication (2014)Improving CRISPR-Cas nuclease specificity using truncated guide RNAsCRISPR
Publication (2014)Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonucleaseCRISPR
Publication (2014)High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cellsCRISPR
Publication (2014)CRISPR-mediated direct mutation of cancer genes in the mouse liverCRISPR
Publication (2014)Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complexCRISPR
Publication (2014)Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivationCRISPR
Publication (2014)High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairsCRISPR
Publication (2014)CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequencesCRISPR
Publication (2014)Genome-Scale CRISPR-Cas9 knockout screening in human cellsCRISPR
Publication (2014)Genetic screens in human cells using the CRISPR-Cas9 systemCRISPR
Publication (2014)Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cellsCRISPR
Publication (2014)Dimeric CRISPR RNA-guided FokI nucleases for efficient genome editingCRISPR
Publication (2014)CasOT: a genome-wide Cas9/gRNA off-target searching toolCRISPR
Publication (2014)Classification and evolution of type II CRISPR-Cas systemsCRISPR
Publication (2014)Development and applications of CRISPR-Cas9 for genome engineeringCRISPR
Publication (2014)Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonucleaseCRISPR
Publication (2014)Synthetic TAL effectors for targeted enhancement of transgene expression in plantsTALEN
Publication (2013)Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexesCRISPR
Publication (2013)Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and DeletionsCRISPR
Publication (2013)Targeted Heritable Mutation and Gene Conversion by Cas9-CRISPR in Caenorhabditis elegansCRISPR
Publication (2013)Transgene-Free Genome Editing in Caenorhabditis elegans Using CRISPR-CasCRISPR
Publication (2013)The CRISPR/Cas System mediates efficient genome engineering in Bombyx moriCRISPR
Publication (2013)Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in DrosophilaCRISPR
Publication (2013)Efficient genome editing in zebrafish using a CRISPR-Cas systemCRISPR
Publication (2013)Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafishCRISPR
Publication (2013)Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease systemCRISPR
Publication (2013)Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas SystemCRISPR
Publication (2013)Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryosCRISPR
Publication (2013)Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalisCRISPR
Publication (2013)Effective gene targeting in rabbits using RNA-guided Cas9 nucleasesCRISPR
Publication (2013)Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systemsCRISPR
Publication (2013)Heritable gene targeting in the mouse and rat using a CRISPR-Cas systemCRISPR
Publication (2013)Generation of gene-modified mice via Cas9/RNA-mediated gene targetingCRISPR
Publication (2013)Heritable Gene Knockout in Caenorhabditis elegans by Direct Injection of Cas9–sgRNA RibonucleoproteinsCRISPR
Publication (2013)High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificityCRISPR
Publication (2013)Phylogeny of Cas9 determines functional exchange ability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systemsCRISPR
Publication (2013)Genotyping with CRISPR-Cas-derived RNA-guided endonucleasesCRISPR
Publication (2013)crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilusCRISPR
Publication (2013)Programmable DNA cleavage in vitro by Cas9CRISPR
Publication (2013)Genome engineering in cerevisiae using CRISPR-Cas systemsCRISPR
Publication (2013)RNA-guided editing of bacterial genomes using CRISPR-Cas systemsCRISPR
Publication (2013)Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas systemCRISPR
Publication (2013)Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9CRISPR
Publication (2013)Targeted genome modification of crop plants using a CRISPR-Cas systemCRISPR
Publication (2013)Heritable genome editing in C. elegans via a CRISPR-Cas9 systemCRISPR
Publication (2013)CRISPR/Cas9-Targeted Mutagenesis in Caenorhabditis elegansCRISPR
Publication (2013)Heritable Custom Genomic Modifications in Caenorhabditis elegans via a CRISPR–Cas9 SystemCRISPR
Publication (2013)Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 NucleaseCRISPR
Publication (2013)Multiplex Genome Engineering Using CRISPR/Cas SystemsCRISPR
Publication (2013)RNA-programmed genome editing in human cellsCRISPR
Publication (2013)Targeted genome engineering in human cells with the Cas9 RNA-guided endonucleaseCRISPR
Publication (2013)CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineeringCRISPR
Publication (2013)High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cellsCRISPR
Publication (2013)DNA targeting specificity of RNA-guided Cas9 nucleasesCRISPR
Publication (2013)Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirusCRISPR
Publication (2013)CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activityCRISPR
Publication (2013)Orthogonal Cas9 proteins for RNA-guided gene regulation and editingCRISPR
Publication (2013)Efficient generation of large-scale genome-modified mice using gRNA and Cas9 endonucleaseCRISPR
Publication (2013)Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificityCRISPR
Publication (2013)Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expressionCRISPR
Publication (2013)Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas systemCRISPR
Publication (2013)CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotesCRISPR
Publication (2013)Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and riceCRISPR
Publication (2013)Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNACRISPR
Publication (2013)Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidisCRISPR
Publication (2013)The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systemsCRISPR
Publication (2013)High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. TALEN
Publication (2012)A CRISPR/Cas system mediates bacterial innate immune evasion and virulenceCRISPR
Publication (2012)Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteriaCRISPR
Publication (2012)RNA-Guided Human Genome Engineering via Cas9CRISPR
Publication (2012)A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunityCRISPR
Publication (2012)Obligate Ligation-Gated Recombination (ObLiGaRe): Custom-designed nuclease-mediated targeted integration through nonhomologous end joiningCRISPR
Publication (2011)The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coliCRISPR
Publication (2011)CRISPR RNA maturation by trans-encoded small RNA and host factor RNase IIICRISPR
Publication (2011)A TALE nuclease architecture for efficient genome editing TALEN
Publication (2011)Assembly of custom TALE-type DNA binding domains by modular cloningTALEN
Publication (2011)Genetic engineering of human pluripotent cells using TALE nucleasesTALEN
Publication (2011)Transcriptional Activators of Human Genes with Programmable DNA-SpecificityTALEN
Publication (2011)Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targetingTALEN
Publication (2011)Efficient construction of sequence-specific TAL effectors for modulating mammalian transcriptionTALEN
Publication (2009)Short motif sequences determine the targets of prokaryotic CRISPR defence systemCRISPR
Publication (2009)Breaking the code of DNA binding specificity of TAL-type III effectorsTALEN
Publication (2009)A simple cipher governs DNA recognition by TAL effectorsTALEN
Publication (2007)CRISPR provides acquired resistance against viruses in prokaryotesCRISPR
Publication (2005)Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal originCRISPR
TrainingGene editing in pluripotent stem cellsCRISPR
VideoGenome editing video collectionCRISPR
WebinarGenome editing webinar collectionCRISPR, TALEN

For Research Use Only. Not for use in diagnostic procedures.