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Genome Editing Resource Library

Within the Genome Editing Learning Center, the Resource Library is where you can connect to all our different educational, technical, application, and other learning materials by resource collection. This includes webinars & videos, application notes & poster presentations, validated protocols, and publications.

To browse learning content by genome editing application subtopic, visit the main Genome Editing Learning Center home.

Resource library collections

Genome Editing Videos & Webinars

From general overviews of CRISPR and TALEN-based genome editing techniques and experimental design best practices to specific applications including cell engineering and knock-in/-out strategies, our collection of videos and webinars is designed to help you maximize your success using these technologies.

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Type Name Genome editing technology
Application Note Powerful loss-of-function screening with LentiArray CRISPR gRNAs: maximize knockout efficiency while maintaining specificity CRISPR-Cas9
Application note Application Note: Achieve functional knockout in up to 90% of human primary T cells CRISPR-Cas9
Application note Delivery solutions for immune cells CRISPR-Cas9
Application note Improve genome editing outcomes in biologically relevant cell models CRISPR-Cas9, TALEN
Application note Using Sanger sequencing to facilitate CRISPR and TALEN-mediated genome editing workflows CRISPR-Cas9, TALEN
FAQs CRISPR-based genome editing—Getting Started FAQs CRISPR-Cas9
FAQs CRISPR-based genome editing—Troubleshooting FAQs CRISPR-Cas9
FAQs TALEN-based genome editing—Getting Started FAQs TALEN
FAQs TALEN-based genome editing—Troubleshooting FAQs TALEN
Infographic Genome Editing With Engineered Nucleases CRISPR-Cas9
Infographic The Evolution of Genome Editing CRISPR-Cas9
Protocol General CRISPR RNP Transfection Guidelines CRISPR-Cas9
Protocol Verification of CRISPR Gene Editing Efficiency CRISPR-Cas9
Protocol Guidelines For Clone Isolation and Validation CRISPR-Cas9
Protocol Cell-Line Specific CRISPR RNP Transfection Conditions Using Lipofectamine CRISPRMAX Reagent CRISPR-Cas9
Protocol Cell-Line Specific CRISPR RNP Electroporation Conditions Using Neon System CRISPR-Cas9
Protocol Embryo Microinjection With CRISPR-Cas9 in Mice and Zebrafish CRISPR-Cas9
Protocol CRISPR-Cas9 Genome Editing In Human Induced Pluripotent Stem Cell CRISPR-Cas9
Publication (2016) Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA CRISPR-Cas9
Publication (2016) Improved delivery of Cas9 protein/gRNA complexes using lipofectamine CRISPRMAX CRISPR-Cas9
Publication (2015) Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection. CRISPR-Cas9
Publication (2015) Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. CRISPR-Cas9
Publication (2015) Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease CRISPR-Cas9
Publication (2015) Efficient Intracellular Delivery of Native Proteins CRISPR-Cas9
Publication (2015) CRISPR/Cas9 nuclease cleavage combined with Gibson assembly for seamless cloning. CRISPR-Cas9
Publication (2015) Engineered CRISPR-Cas9 nucleases with altered PAM specificities CRISPR-Cas9
Publication (2015) Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers CRISPR-Cas9
Publication (2015) Digienome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells CRISPR-Cas9
Publication (2015) In vivo genome editing using Staphylococcus aureus Cas9 CRISPR-Cas9
Publication (2015) Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors CRISPR-Cas9
Publication (2015) Multiplex conditional mutagenesis using transgenic expression of Cas9 and sgRNAs CRISPR-Cas9
Publication (2015) Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells CRISPR-Cas9
Publication (2015) A Cas9–guide RNA complex preorganized for target DNA recognition CRISPR-Cas9
Publication (2014) Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases CRISPR-Cas9
Publication (2014) Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects CRISPR-Cas9
Publication (2014) DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 CRISPR-Cas9
Publication (2014) Programmable RNA recognition and cleavage by CRISPR/Cas9 CRISPR-Cas9
Publication (2014) Landscape of target: guide homology effects on Cas9-mediated cleavage CRISPR-Cas9
Publication (2014) Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA CRISPR-Cas9
Publication (2014) Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter CRISPR-Cas9
Publication (2014) Crystal structure of Cas9 in complex with guide RNA and target DNA CRISPR-Cas9
Publication (2014) Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo  CRISPR-Cas9
Publication (2014) Guide RNA functional modules direct Cas9 activity and orthogonality CRISPR-Cas9
Publication (2014) Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage CRISPR-Cas9
Publication (2014) Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool CRISPR-Cas9
Publication (2014) GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases CRISPR-Cas9
Publication (2014) Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation CRISPR-Cas9
Publication (2014) Improving CRISPR-Cas nuclease specificty using truncated guide RNAs CRISPR-Cas9
Publication (2014) Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease CRISPR-Cas9
Publication (2014) High-throuput screening of a CRISPR/Cas9 library for functional genomics in human cells CRISPR-Cas9
Publication (2014) CRISPR-mediated direct mutation of cancer genes in the mouse liver CRISPR-Cas9
Publication (2014) Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex CRISPR-Cas9
Publication (2014) Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation CRISPR-Cas9
Publication (2014) High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zince finger nucleases or CRISPR/Cas9 nickase pairs CRISPR-Cas9
Publication (2014) CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences CRISPR-Cas9
Publication (2014) Genome-Scale CRISPR-Cas9 knockout screening in human cells CRISPR-Cas9
Publication (2014) Genetic screens in human cells using the CRISPR-Cas9 system CRISPR-Cas9
Publication (2014) Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells CRISPR-Cas9
Publication (2014) Dimeric CRISPR RNA-guided FokI nucleases for efficient genome editing CRISPR-Cas9
Publication (2014) CasOT: a genome-wide Cas9/gRNA off-target searching tool CRISPR-Cas9
Publication (2014) Classification and evolution of type II CRISPR-Cas systems CRISPR-Cas9
Publication (2014) Development and applications of CRISPR-Cas9 for genome engineering CRISPR-Cas9
Publication (2014) Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease CRISPR-Cas9
Publication (2014) Synthetic TAL effectors for targeted enhancement of transgene expression in plants TALEN
Publication (2013) Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes CRISPR-Cas9
Publication (2013) Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions CRISPR-Cas9
Publication (2013) Targeted Heritable Mutation and Gene Conversion by Cas9-CRISPR in Caenorhabditis elegans CRISPR-Cas9
Publication (2013) Transgene-Free Genome Editing in Caenorhabditis elegans Using CRISPR-Cas CRISPR-Cas9
Publication (2013) The CRISPR/Cas System mediates efficient genome engineering in Bombyx mori CRISPR-Cas9
Publication (2013) Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila CRISPR-Cas9
Publication (2013) Efficient genome editing in zebrafish using a CRISPR-Cas system CRISPR-Cas9
Publication (2013) Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish CRISPR-Cas9
Publication (2013) Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system CRISPR-Cas9
Publication (2013) Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System CRISPR-Cas9
Publication (2013) Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos CRISPR-Cas9
Publication (2013) Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis CRISPR-Cas9
Publication (2013) Effective gene targeting in rabbits using RNA-guided Cas9 nucleases CRISPR-Cas9
Publication (2013) Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems CRISPR-Cas9
Publication (2013) Heritable gene targeting in the mouse and rat using a CRISPR-Cas system CRISPR-Cas9
Publication (2013) Generation of gene-modified mice via Cas9/RNA-mediated gene targeting CRISPR-Cas9
Publication (2013) Heritable Gene Knockout in Caenorhabditis elegans by Direct Injection of Cas9–sgRNA Ribonucleoproteins CRISPR-Cas9
Publication (2013) High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity CRISPR-Cas9
Publication (2013) Phylogeny of Cas9 determines functional exchange ability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems CRISPR-Cas9
Publication (2013) Genotyping with CRISPR-Cas-derived RNA-guided endonucleases CRISPR-Cas9
Publication (2013) crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus CRISPR-Cas9
Publication (2013) Programmable DNA cleavage in vitro by Cas9 CRISPR-Cas9
Publication (2013) Genome engineering in cerevisiae using CRISPR-Cas systems CRISPR-Cas9
Publication (2013) RNA-guided editing of bacterial genomes using CRISPR-Cas systems CRISPR-Cas9
Publication (2013) Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system CRISPR-Cas9
Publication (2013) Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 CRISPR-Cas9
Publication (2013) Targeted genome modification of crop plants using a CRISPR-Cas system CRISPR-Cas9
Publication (2013) Heritable genome editing in C. elegans via a CRISPR-Cas9 system CRISPR-Cas9
Publication (2013) CRISPR/Cas9-Targeted Mutagenesis in Caenorhabditis elegans CRISPR-Cas9
Publication (2013) Heritable Custom Genomic Modifications in Caenorhabditis elegans via a CRISPR–Cas9 System CRISPR-Cas9
Publication (2013) Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease CRISPR-Cas9
Publication (2013) Multiplex Genome Engineering Using CRISPR/Cas Systems CRISPR-Cas9
Publication (2013) RNA-programmed genome editing in human cells CRISPR-Cas9
Publication (2013) Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease CRISPR-Cas9
Publication (2013) CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering CRISPR-Cas9
Publication (2013) High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells CRISPR-Cas9
Publication (2013) DNA targeting specificity of RNA-guided Cas9 nucleases CRISPR-Cas9
Publication (2013) Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus CRISPR-Cas9
Publication (2013) CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity CRISPR-Cas9
Publication (2013) Orthogonal Cas9 proteins for RNA-guided gene regulation and editing CRISPR-Cas9
Publication (2013) Efficient generation of large-scale genome-modified mice using gRNA and Cas9 endonuclease CRISPR-Cas9
Publication (2013) Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity CRISPR-Cas9
Publication (2013) Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression CRISPR-Cas9
Publication (2013) Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system CRISPR-Cas9
Publication (2013) CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes CRISPR-Cas9
Publication (2013) Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice CRISPR-Cas9
Publication (2013) Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA CRISPR-Cas9
Publication (2013) Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis CRISPR-Cas9
Publication (2013) The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems CRISPR-Cas9
Publication (2013) High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.  TALEN
Publication (2012) A CRISPR/Cas system mediates bacterial innate immune evasion and virulence CRISPR-Cas9
Publication (2012) Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria CRISPR-Cas9
Publication (2012) RNA-Guided Human Genome Engineering via Cas9 CRISPR-Cas9
Publication (2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity CRISPR-Cas9
Publication (2012) Obligate Ligation-Gated Recobmination (ObLiGaRe): Custom-designed nuclease-mdediated targeted integration through nonhomologous end joining CRISPR-Cas9
Publication (2011) The Streptococcus thermophilus CRISPR/Cas system provides immunity in Eschrichia coli CRISPR-Cas9
Publication (2011) CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III CRISPR-Cas9
Publication (2011) A TALE nuclease architecture for efficient genome editing  TALEN
Publication (2011) Assembly of custom TALE-type DNA binding domains by modular cloning TALEN
Publication (2011) Genetic engineering of human pluripotent cells using TALE nucleases TALEN
Publication (2011) Transcriptional Activators of Human Genes with Programmable DNA-Specificity TALEN
Publication (2011) Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting TALEN
Publication (2011) Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription TALEN
Publication (2009) Short motif sequences determine the targets of prokarytoic CRISPR defence system CRISPR-Cas9
Publication (2009) Breaking the code of DNA binding specificity of TAL-type III effectors TALEN
Publication (2009) A simple cipher governs DNA recognition by TAL effectors TALEN
Publication (2007) CRISPR provides acquired resistance against viruses in prokaryotes CRISPR-Cas9
Publication (2005) Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin CRISPR-Cas9
Resource guide CRISPR-Cas9 Protein for Genome Editing—Getting Started Guide CRISPR-Cas9
Resource guide Genome Editing Resource Guide CRISPR-Cas9, TALEN
Video Genome editing video collection CRISPR-Cas9
Webinar Genome editing webinars CRISPR-Cas9, TALEN