Application note | Improving and simplifying the design of knock-in experiments using the TrueDesign Genome Editor | CRISPR, TALEN |
Application note | Improve genome editing outcomes in biologically relevant cell models | CRISPR, TALEN |
Application note | Key considerations in genome editing | CRISPR, TALEN |
Application note | Powerful loss-of-function screening with LentiArray CRISPR gRNAs: maximize knockout efficiency while maintaining specificity | CRISPR |
Application note | Using Sanger sequencing to facilitate CRISPR and TALEN-mediated genome editing workflows | CRISPR, TALEN |
Article | CRISPR-generated CAR-T cells: A new frontier in the treatment of solid tumors | CRISPR |
Article | Collaboration and CRISPR tools move scientists closer to a cure for sight loss | CRISPR |
Article | Design your CRISPR gene editing experiments in as little as five minutes | CRISPR, TALEN |
Article | Looking to overcome challenges in your gene editing workflow? | CRISPR, TALEN |
Article | Modeling rare diseases using CRISPR gene editing—Could fruit flies save lives? | CRISPR |
Article | Revolutionizing drug discovery: The role of CRISPR gene editing in target validation | CRISPR |
Brochure | CRISPR-Cas9 Protein for Genome Editing—Getting Started Guide | CRISPR |
Brochure | CRISPR Genome Editing Tools | CRISPR |
FAQs | CRISPR-based genome editing—Getting Started FAQs | CRISPR |
FAQs | CRISPR-based genome editing—Troubleshooting FAQs | CRISPR |
FAQs | TALEN-based genome editing—Getting Started FAQs | TALEN |
FAQs | TALEN-based genome editing—Troubleshooting FAQs | TALEN |
Handbook | Genome Editing Resource Guide | CRISPR, TALEN |
Interview | CRISPR-Cas9: A transformative tool for treating debilitating genetic disease | CRISPR |
Interview | How CRISPR provides a unique opportunity to generate rare disease avatars | CRISPR |
Infographic | Cas9 Plasmids vs Proteins | CRISPR |
Infographic | CRISPR-Cas9 - A promising tool for therapeutics development | CRISPR |
Infographic | Tips & Tricks for CRISPR Success | CRISPR |
Protocol | CRISPR-Cas9 Genome Editing In Human Induced Pluripotent Stem Cell | CRISPR |
Protocol | Cell-Line Specific CRISPR RNP Transfection Conditions Using Lipofectamine CRISPRMAX Reagent | CRISPR |
Protocol | Cell-Line Specific CRISPR RNP Electroporation Conditions Using Neon System | CRISPR |
Protocol | Embryo Microinjection With CRISPR-Cas9 in Mice and Zebrafish | CRISPR |
Protocol | General CRISPR RNP Transfection Guidelines | CRISPR |
Protocol | Guidelines For Clone Isolation and Validation | CRISPR |
Protocol | Verification of CRISPR Gene Editing Efficiency | CRISPR |
Publication (2023) | High-Efficiency CRISPR/Cas9-Mediated Correction of a Homozygous Mutation in Achromatopsia-Patient-Derived iPSCs | CRISPR |
Publication (2023) | Target-seq: single workflow for detection of genome integration site, DNA translocation and off-target events | CRISPR, TALEN |
Publication (2022) | Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL | CRISPR, TALEN |
Publication (2020) | A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries | CRISPR |
Publication (2020) | Development of a Proline-Based Selection System for Reliable Genetic Engineering in Chinese Hamster Ovary Cells | CRISPR, TALEN |
Publication (2019) | Lipofection-mediated genome editing using DNA-free delivery of the Cas9/gRNA ribonucleoprotein into plant cells | CRISPR |
Publication (2018) | Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting | CRISPR |
Publication (2018) | TEG-seq: an ion torrent-adapted NGS workflow for in cellulo mapping of CRISPR specificity | CRISPR |
Publication (2017) | Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA | CRISPR |
Publication (2017) | Programmable type III-A CRISPR-Cas DNA targeting modules | CRISPR |
Publication (2016) | Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA | CRISPR |
Publication (2016) | Improved delivery of Cas9 protein/gRNA complexes using lipofectamine CRISPRMAX | CRISPR |
Publication (2015) | Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection. | CRISPR |
Publication (2015) | Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. | CRISPR |
Publication (2015) | Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease | CRISPR |
Publication (2015) | Efficient Intracellular Delivery of Native Proteins | CRISPR |
Publication (2015) | CRISPR/Cas9 nuclease cleavage combined with Gibson assembly for seamless cloning. | CRISPR |
Publication (2015) | Engineered CRISPR-Cas9 nucleases with altered PAM specificities | CRISPR |
Publication (2015) | Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers | CRISPR |
Publication (2015) | Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells | CRISPR |
Publication (2015) | In vivo genome editing using Staphylococcus aureus Cas9 | CRISPR |
Publication (2015) | Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors | CRISPR |
Publication (2015) | Multiplex conditional mutagenesis using transgenic expression of Cas9 and sgRNAs | CRISPR |
Publication (2015) | Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells | CRISPR |
Publication (2015) | A Cas9–guide RNA complex preorganized for target DNA recognition | CRISPR |
Publication (2014) | Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases | CRISPR |
Publication (2014) | Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects | CRISPR |
Publication (2014) | DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 | CRISPR |
Publication (2014) | Programmable RNA recognition and cleavage by CRISPR/Cas9 | CRISPR |
Publication (2014) | Landscape of target: guide homology effects on Cas9-mediated cleavage | CRISPR |
Publication (2014) | Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA | CRISPR |
Publication (2014) | Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter | CRISPR |
Publication (2014) | Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo | CRISPR |
Publication (2014) | Guide RNA functional modules direct Cas9 activity and orthogonality | CRISPR |
Publication (2014) | Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage | CRISPR |
Publication (2014) | Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool | CRISPR |
Publication (2014) | GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases | CRISPR |
Publication (2014) | Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation | CRISPR |
Publication (2014) | Improving CRISPR-Cas nuclease specificity using truncated guide RNAs | CRISPR |
Publication (2014) | Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease | CRISPR |
Publication (2014) | High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells | CRISPR |
Publication (2014) | CRISPR-mediated direct mutation of cancer genes in the mouse liver | CRISPR |
Publication (2014) | Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex | CRISPR |
Publication (2014) | Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation | CRISPR |
Publication (2014) | High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs | CRISPR |
Publication (2014) | CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences | CRISPR |
Publication (2014) | Genome-Scale CRISPR-Cas9 knockout screening in human cells | CRISPR |
Publication (2014) | Genetic screens in human cells using the CRISPR-Cas9 system | CRISPR |
Publication (2014) | Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells | CRISPR |
Publication (2014) | Dimeric CRISPR RNA-guided FokI nucleases for efficient genome editing | CRISPR |
Publication (2014) | CasOT: a genome-wide Cas9/gRNA off-target searching tool | CRISPR |
Publication (2014) | Classification and evolution of type II CRISPR-Cas systems | CRISPR |
Publication (2014) | Development and applications of CRISPR-Cas9 for genome engineering | CRISPR |
Publication (2014) | Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease | CRISPR |
Publication (2014) | Synthetic TAL effectors for targeted enhancement of transgene expression in plants | TALEN |
Publication (2013) | Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes | CRISPR |
Publication (2013) | Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions | CRISPR |
Publication (2013) | Targeted Heritable Mutation and Gene Conversion by Cas9-CRISPR in Caenorhabditis elegans | CRISPR |
Publication (2013) | Transgene-Free Genome Editing in Caenorhabditis elegans Using CRISPR-Cas | CRISPR |
Publication (2013) | The CRISPR/Cas System mediates efficient genome engineering in Bombyx mori | CRISPR |
Publication (2013) | Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila | CRISPR |
Publication (2013) | Efficient genome editing in zebrafish using a CRISPR-Cas system | CRISPR |
Publication (2013) | Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish | CRISPR |
Publication (2013) | Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system | CRISPR |
Publication (2013) | Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System | CRISPR |
Publication (2013) | Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos | CRISPR |
Publication (2013) | Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis | CRISPR |
Publication (2013) | Effective gene targeting in rabbits using RNA-guided Cas9 nucleases | CRISPR |
Publication (2013) | Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems | CRISPR |
Publication (2013) | Heritable gene targeting in the mouse and rat using a CRISPR-Cas system | CRISPR |
Publication (2013) | Generation of gene-modified mice via Cas9/RNA-mediated gene targeting | CRISPR |
Publication (2013) | Heritable Gene Knockout in Caenorhabditis elegans by Direct Injection of Cas9–sgRNA Ribonucleoproteins | CRISPR |
Publication (2013) | High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity | CRISPR |
Publication (2013) | Phylogeny of Cas9 determines functional exchange ability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems | CRISPR |
Publication (2013) | Genotyping with CRISPR-Cas-derived RNA-guided endonucleases | CRISPR |
Publication (2013) | crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus | CRISPR |
Publication (2013) | Programmable DNA cleavage in vitro by Cas9 | CRISPR |
Publication (2013) | Genome engineering in cerevisiae using CRISPR-Cas systems | CRISPR |
Publication (2013) | RNA-guided editing of bacterial genomes using CRISPR-Cas systems | CRISPR |
Publication (2013) | Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system | CRISPR |
Publication (2013) | Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 | CRISPR |
Publication (2013) | Targeted genome modification of crop plants using a CRISPR-Cas system | CRISPR |
Publication (2013) | Heritable genome editing in C. elegans via a CRISPR-Cas9 system | CRISPR |
Publication (2013) | CRISPR/Cas9-Targeted Mutagenesis in Caenorhabditis elegans | CRISPR |
Publication (2013) | Heritable Custom Genomic Modifications in Caenorhabditis elegans via a CRISPR–Cas9 System | CRISPR |
Publication (2013) | Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease | CRISPR |
Publication (2013) | Multiplex Genome Engineering Using CRISPR/Cas Systems | CRISPR |
Publication (2013) | RNA-programmed genome editing in human cells | CRISPR |
Publication (2013) | Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease | CRISPR |
Publication (2013) | CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering | CRISPR |
Publication (2013) | High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells | CRISPR |
Publication (2013) | DNA targeting specificity of RNA-guided Cas9 nucleases | CRISPR |
Publication (2013) | Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus | CRISPR |
Publication (2013) | CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity | CRISPR |
Publication (2013) | Orthogonal Cas9 proteins for RNA-guided gene regulation and editing | CRISPR |
Publication (2013) | Efficient generation of large-scale genome-modified mice using gRNA and Cas9 endonuclease | CRISPR |
Publication (2013) | Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity | CRISPR |
Publication (2013) | CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes | CRISPR |
Publication (2013) | Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice | CRISPR |
Publication (2013) | Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA | CRISPR |
Publication (2013) | Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis | CRISPR |
Publication (2013) | The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems | CRISPR |
Publication (2013) | High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. | TALEN |
Publication (2012) | A CRISPR/Cas system mediates bacterial innate immune evasion and virulence | CRISPR |
Publication (2012) | Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria | CRISPR |
Publication (2012) | RNA-Guided Human Genome Engineering via Cas9 | CRISPR |
Publication (2012) | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity | CRISPR |
Publication (2012) | Obligate Ligation-Gated Recombination (ObLiGaRe): Custom-designed nuclease-mediated targeted integration through nonhomologous end joining | CRISPR |
Publication (2011) | The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli | CRISPR |
Publication (2011) | CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III | CRISPR |
Publication (2011) | A TALE nuclease architecture for efficient genome editing | TALEN |
Publication (2011) | Assembly of custom TALE-type DNA binding domains by modular cloning | TALEN |
Publication (2011) | Genetic engineering of human pluripotent cells using TALE nucleases | TALEN |
Publication (2011) | Transcriptional Activators of Human Genes with Programmable DNA-Specificity | TALEN |
Publication (2011) | Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting | TALEN |
Publication (2011) | Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription | TALEN |
Publication (2009) | Short motif sequences determine the targets of prokaryotic CRISPR defence system | CRISPR |
Publication (2009) | Breaking the code of DNA binding specificity of TAL-type III effectors | TALEN |
Publication (2009) | A simple cipher governs DNA recognition by TAL effectors | TALEN |
Publication (2007) | CRISPR provides acquired resistance against viruses in prokaryotes | CRISPR |
Publication (2005) | Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin | CRISPR |
Training | Gene editing in pluripotent stem cells | CRISPR |
Video | Genome editing video collection | CRISPR |
Webinar | Genome editing webinar collection | CRISPR, TALEN |