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Introducing the first-to-market, third party certified cleanroom compatible CO2 incubator. Suitable for ISO Class 5 and Good Manufacturing Practices (GMP) grade A/B environments. Thermo Scientific Heracell Vios CR CO2 Incubators and Thermo Scientific Forma Steri-Cycle CR CO2 Incubators feature an active particle control system and demonstrated compatibility with commonly used cleanroom cleaning methods, making it the perfect fit for your cleanroom suite or GMP production environment.
Cleanroom compatible CO2 incubators
Cleanroom certified
Through rigorous testing, the Heracell Vios CR / Forma Steri-Cycle CR incubators have successfully achieved ISO class 5 compatibility for the considered particle sizes in both standard operating and sterilization modes.
Robust and easy to clean
In cleanroom environments, CO2 incubators need to be robust enough to withstand the thorough cleaning procedures required. The Vios CR / Steri-Cycle CR incubator exterior is easier to clean and maintain.
GMP documentation package
The industrial design has been tested and independently validated to ensure it meets the needs of evolving cleanroom and GMP production environments. A complete factory documentation package is included.
Watch the video to learn more about certified cleanroom compatible CO2 incubators
Choose the CO2 incubator for your cleanroom
| Heracell Vios 160i CR | Heracell Vios 250i CR | |
 |  | |
| Description | Advanced incubator design for high value cells | Advanced large capacity for high value cells and high throughput labs |
| Capacity | 165 L (5.8 cu. ft.) | 255 L (9.0 cu. ft.) |
| Chamber type | Direct heat | Direct heat |
| Door swing | Right hinged | Right hinged |
| Exterior material | Brushed 304 L stainless steel | Brushed 304 L stainless steel |
| Choose interior | 304 Stainless steel › 100% copper › Cell Locker System (configurable system) › | 304 Stainless steel › 100% copper › |
| Sterilization | Steri-Run (180°) | Steri-Run (180°) |
| IP rating | IP54 rated | IP54 rated |
| In-chamber HEPA filtration | ISO Class 5 interior conditions | ISO Class 5 interior conditions |
| Active particle control system | ISO Class 5 GMP grade A/B external conditions | ISO Class 5 GMP grade A/B external conditions |
| Airlfow technology | THRIVE: | THRIVE: |
| CO2 sensors | IR180Si | IR180Si |
| O2 control | Optional 1-21% or 5-90% | Optional 1-21% or 5-90% |
| Humidity | Covered integrated reservoir with easy draining | Covered integrated reservoir with easy draining |
| User interface | iCAN touch screen | iCAN touch screen |
| Documentation package | Included | Included |
| Data output | 4-20 mA standard | 4-20 mA standard |
| Forma Steri-Cycle 160i CR | Forma Steri-Cycle 250i CR | |
 |  | |
| Description | Advanced incubator design for high value cells | Advanced large capacity for high value cells and high throughput labs |
| Capacity | 165 L (5.8 cu. ft.) | 255 L (9.0 cu. ft.) |
| Chamber type | Direct heat | Direct heat |
| Door swing | Right hinged | Right hinged |
| Exterior material | Brushed 304 L stainless steel | Brushed 304 L stainless steel |
| Choose interior | 304 Stainless steel › 100% copper › Cell Locker System (configurable system) › | 304 Stainless steel › 100% copper › |
| Sterilization | Steri-Run (180°) | Steri-Run (180°) |
| IP Rating | IP54 rated | IP54 rated |
| In-chamber HEPA filtration | ISO Class 5 interior conditions | ISO Class 5 interior conditions |
| Active particle control system | ISO Class 5 GMP grade A/B external conditions | ISO Class 5 GMP grade A/B external conditions |
| Airlfow technology | THRIVE | THRIVE |
| CO2 sensors | IR180Si | IR180Si |
| O2 control | Optional 1-21% or 5-90% | Optional 1-21% or 5-90% |
| Humidity | Covered integrated reservoir with easy draining | Covered integrated reservoir with easy draining |
| User interface | iCAN touch screen | iCAN touch screen |
| Documentation Package | Included | Included |
| Data output | 4-20 mA standard | 4-20 mA standard |
| Heracell Vios 160i CR | Heracell Vios 250i CR | |
| | |
| Description | Advanced incubator design for high value cells | Advanced large capacity for high value cells and high throughput labs |
| Capacity | 165 L (5.8 cu. ft.) | 255 L (9.0 cu. ft.) |
| Chamber type | Direct heat | Direct heat |
| Door swing | Right hinged | Right hinged |
| Exterior material | Brushed 304 L stainless steel | Brushed 304 L stainless steel |
| Choose interior | 304 Stainless steel › 100% copper › Cell Locker System (configurable system) › | 304 Stainless steel › 100% copper › |
| Sterilization | Steri-Run (180°) | Steri-Run (180°) |
| IP rating | IP54 rated | IP54 rated |
| In-chamber HEPA filtration | ISO Class 5 interior conditions | ISO Class 5 interior conditions |
| Active particle control system | ISO Class 5 GMP grade A/B external conditions | ISO Class 5 GMP grade A/B external conditions |
| Airlfow technology | THRIVE: | THRIVE: |
| CO2 sensors | IR180Si | IR180Si |
| O2 control | Optional 1-21% or 5-90% | Optional 1-21% or 5-90% |
| Humidity | Covered integrated reservoir with easy draining | Covered integrated reservoir with easy draining |
| User interface | iCAN touch screen | iCAN touch screen |
| Documentation package | Included | Included |
| Data output | 4-20 mA standard | 4-20 mA standard |
| Forma Steri-Cycle 160i CR | Forma Steri-Cycle 250i CR | |
| | |
| Description | Advanced incubator design for high value cells | Advanced large capacity for high value cells and high throughput labs |
| Capacity | 165 L (5.8 cu. ft.) | 255 L (9.0 cu. ft.) |
| Chamber type | Direct heat | Direct heat |
| Door swing | Right hinged | Right hinged |
| Exterior material | Brushed 304 L stainless steel | Brushed 304 L stainless steel |
| Choose interior | 304 Stainless steel › 100% copper › Cell Locker System (configurable system) › | 304 Stainless steel › 100% copper › |
| Sterilization | Steri-Run (180°) | Steri-Run (180°) |
| IP Rating | IP54 rated | IP54 rated |
| In-chamber HEPA filtration | ISO Class 5 interior conditions | ISO Class 5 interior conditions |
| Active particle control system | ISO Class 5 GMP grade A/B external conditions | ISO Class 5 GMP grade A/B external conditions |
| Airlfow technology | THRIVE | THRIVE |
| CO2 sensors | IR180Si | IR180Si |
| O2 control | Optional 1-21% or 5-90% | Optional 1-21% or 5-90% |
| Humidity | Covered integrated reservoir with easy draining | Covered integrated reservoir with easy draining |
| User interface | iCAN touch screen | iCAN touch screen |
| Documentation Package | Included | Included |
| Data output | 4-20 mA standard | 4-20 mA standard |
Explore the Vios Cleanroom Incubators
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Heracell Vios 160i CR CO2 Incubator
360-degree, spin, zoom, rotate, discover and interact with the 165L version of this cleanroom-compatible CO2 incubator.
Heracell Vios 250i CR CO2 Incubator
360-degree, spin, zoom, rotate, discover and interact with the 255L version of this cleanroom-compatible CO2 incubator.
5 Reasons...
 | Learn about cleanroom requirements, sources of particles and risks, what it takes to be a GMP certified incubator, and how different incubators produce very different culture conditions. |
Key Features
Responding to the rising demand for proven cleanroom compatibility, we have met the need with the first active particle control system designed for a CO2 incubator. This innovative technology controls and captures particulates. Air throughout the casing is directed through a HEPA filter in the rear to assure no disruption to the cleanroom environment. This design is independently validated and Certified for ISO Class 5 and GMP Grade A/B environments.
- Brushed 304 stainless steel exterior is compatible with STERISdry non-condensing VHP and 3% manual wipe hydrogen peroxide cleaning methods typically used in cleanroom environments.
- PLUS Sealed exterior casing includes silicone sealed electronics and welded door to contain any particulate risk.
- PLUS IP54 rated componentry protects electronics from dust and is resistant to water spray from any direction.
Documentation package including:
- Regulatory certificates
- Declaration of Conformity (CE) with EU law, CSA and QMS Certificates
- Recommended protocols
- User-replaceable parts and consumables lists
- Product-specific factory documentation and specification
- Certificates of conformance, calibration, and technical specifications
- 3rd party certificate of compatibility with ISO Class 5 and GMP Grade A/B cleanroom environments
Designed to maximize incubator space. |
As you scale out your cell therapy manufacturing, the incubator you have come to trust can now adjust with you. To match your changing needs, our special shelving system options offer additional capacity and/or improved access for specialized cell culture vessels such as Wilson Wolf G-Rex® 500M-CS bioreactors or Thermo Scientific Nunc Cell Factory systems.
These dedicated shelving systems are available as separate accessories. Each offers several advantages as you enter the cell expansion stage using larger cell culture vessels.
 Stainless steel reinforced shelves | Available as accessory | Easy installation and retrofittable |
Fit more large cell culture vessels into your incubator
Optimize your incubator with CultiMaxx shelving systems
| Heracell Vios CR 250i and VIOS 250i Incubator Accessories | Vessel Type | Advantages | Action |
| CultiMaxx shelving system for 1 L cell culture bags |  | Up to 2.5x more culture bag capacity per incubator and increased exposure to promote better gas exchange | Buy now › |
| CultiMaxx shelving system for 10x Nunc Cell Factory 4-layer systems |  | Accommodates 1 more Cell Factory system, easy access, improved clearance for air filters | Buy now › |
| CultiMaxx shelving system for 6x Nunc Cell Factory 10- or 13- systems |  | Easy access, better clearance for air filter | Buy now › |
| CultiMaxx shelving system for up to 10x G-Rex® 500M-CS (or up to 45x 100M-CS or 123x 10M-CS) |  | 150% more capacity compared to standard shelving | Buy now › |
To request further information or to speak to a specialist about finding the best CultiMaxx solution for your CO2 incubator, please contact us ›
Embark on the remarkable
Dedicated equipment for cell and gene therapy manufacturing
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Resources
Style Sheet for Global Design System