Human Genotyping, Pharmacogenomics, and Microbiome Solutions with Microarrays
The Axiom™ Genotyping Solution offers a uniquely flexible choice of customizable arrays or pre-designed arrays with imputation-aware designs covering more populations than any other technology. The proprietary photolithographic arrays help ensure fidelity and consistency across manufacturing batches, with designs available as long as required. All arrays can access imputation-optimized designs enabling combined GWAS, replication, and fine mapping in one study. It is the only genotyping solution that offers a choice of over 10 million wet lab-validated and fully-annotated markers so that any investigator can easily and cost-effectively create optimized array designs for their application.
Applications supported by the Axiom Genotyping Solution
- High-value genotyping of large sample cohorts
- Imputation aware GWAS module for specific populations
- Fully customizable modules covering content targeting transplant research, Inflammation and HLA, eQTL, human disease and Exome.
Direct to consumer applications
- Fully customizable arrays with intelligent marker selection for markers suitable for DTC applications
- Fully automated assay and array processing that helps ensure consistency and minimizes variability.
- Automated analysis of Y-chromosome and mtDNA markers
- Pre-emptive screening of samples to assess pharmacogenomic risk
- Copy number variation (CNV) analysis for copy number states ranging from zero to three-plus for important ADME genes
- Star allele and translation for key actionable genes
Precision medicine research
- Genotyping resource for researchers driving deeper scientific insights into a variety of important health questions related to common and rare inherited diseases
- Deeper scientific insights from clinically relevant variants enabling assessment of actionable genetic risk across a wide range of populations.
- Biomarker identification and validation
- Genome-wide association
- Replication and fine mapping studies
- Exome analysis
- Candidate gene and pathway studies
For high-throughput, high-value genotyping of large sample cohorts to explore the genetics of complex diseases with a single comprehensive low-cost solution
An ideal platform for translational researchers in healthcare, pharma, biobanks and research organizations who are looking to understand how genetic variations affect drug absorption, distribution, metabolism, and excretion (ADME)
Enables the detection of all known microorganisms in a sample with species- and strain-level identification in a single, scalable assay. The proprietary photolithographic arrays help ensure fidelity and consistency across manufacturing batches, with designs available as long as required.
A genotyping solution that offers dense genotyping, reproducible results, and helps ensure that all markers are accessible in every batch for as long as is necessary, features that are vital to the translation of research results into clinical research insight and to the future wide-scale adoption of precision medicine
Axiom™ World Arrays and Population-Optimized Arrays are genotyping panels that offer genetic coverage of rare and common variants for efficient genome-wide disease association studies.
Develop the most effective custom array for your study of human diseases, drug response, or populations. Use variants you provide or choose SNPs from our Axiom™ Genomic Database, the world's largest resource of genotype-tested SNPs.
Improve your discovery power by choosing a more efficient array focused on your study objectives. Our expertise in using imputation-based marker selection enhances the statistical power of your study.
The Genome-Wide Human SNP Array 6.0 features 1.8 million genetic markers, including more than 906,600 single nucleotide polymorphisms (SNPs) and more than 946,000 probes for the detection of copy number variation.
Instruments, software, and services
A multi-channel instrument for both expression and genotyping that seamlessly integrates hybridization, washing, and imaging to provide automated array processing
Automated target preparation helps minimize run-to-run variability and the labor burden associated with complex manual pipetting, helping to improve test reproducibility and laboratory efficiency.
A complete solution to data analysis for all Axiom arrays. From sample and plate QC to automated genotype calling and SNP classification, this easy-to-use software performs analysis in a single step and allows you to view QC results, summary tables, and SNP cluster graphs.
This software uses intensity and genotypes to calculate log2 ratios and B allele frequencies from genotyping data. The Affymetrix™ CNV Viewer is also included, which allows visualization of copy number changes across the genome.
This software enables you to produce accurate HLA types from any Affymetrix genotyping data set containing high-quality genotypes of a select number of predetermined markers.
The Affymetrix Research Services Laboratory for microarrays is a high-throughput genotyping facility that offers affordable and fast genotyping services for large-scale, microarray-based studies.
The Axiom Genotyping Solution
The highest genetic coverage—the Axiom Genomic Database's over 10.7 million genotype-tested SNPs offer the industry's best coverage of common and rare variants from the 1000 Genomes Project Phase III, HapMap, NHGRI, and more. Each variant has been extensively validated in a large number of biological samples to help ensure that it is not due to sequencing error, the minor allele can be reliably detected, and that it performs consistently in the Axiom assay.
Flexible format—design your marker panel with 1,500 to 2.6 million SNPs and indels using the validated markers from the Axiom Genomic Database or your own target sequences
Rapid results—validated markers and workflows help minimize the time needed for experimental design and assay optimization
High-throughput—process more than up to 3,000 samples per week with end-to-end automated sample processing
Automated genotype calling and SNP classification—analyze up to 5,000 samples and export genotype calls for use in downstream analysis
Confidence in your data—pre-optimized reagents and validated workflows combined with empirically validated SNPs to enable reliable results
The Axiom Genotyping Solution includes pre-designed and customized array plates with validated genomic content from the Axiom Genomic Database as well as complete reagent kits, data analysis tools, and a fully automated workflow utilizing GeneTitan Multi-Channel (MC) Instrument.
For Research Use Only. Not for use in diagnostic procedures.