A wide range of products—flexibility for your research

A wide range of surface-activated Dynabeads magnetic beads is available for covalent coupling of ligands to the bead surface. One can choose beads of different sizes, with a hydrophobic or hydrophilic surface, and with a variety of surface chemistries. For optimal results, select the right bead based on ligand type (Table 1). Note that in most applications several Dynabeads products can be used. Depending on the magnetic bead type, the ligand can be directly linked to the bead surface or indirectly linked through a reactive intermediate. Protocols can take place in a single tube, with just a few handling steps.

Table 1. Choose the right surface-activated Dynabeads for your application.

Ligand Target Dynabeads Tosyl-
Dynabeads Amine Dynabeads Epoxy
Antibody Low MW antigen1 or peptide  dotdotdot dotdot dotdot dotdot
Protein or antibody dotdotdot dotdot dot dotdot
Protein complex
dot dot dotdotdot
Organelles dotdot     dotdot2
Phage1 dotdotdot dotdot dotdot dotdot
Virus dotdotdot dotdot dotdot dotdot
Bacteria dotdotdot dotdot    
Cells3 dotdotdot dotdot   dotdotdot
Antibody Fragment Phage1 or antibody dotdot dotdotdot dotdotdot dotdot
Protein Phage or carbohydrate dotdot dotdot dotdot dotdotdot
Nucleic acid dot dotdotdot dot dot
Peptide Phage1 or antibody dotdot dotdotdot dotdotdot dotdot
Carbohydrate Antibody   dot dotdotdot dot
Low MV antigen Antibody dotdot dotdot dotdot dotdot
Nucleic acids, oligonucleotide, aptamer, PNA Nucleic acid binding proteins1 dot dotdot dot4  
DNA1, RNA1 or PCR amplicons1   dotdotdot dot4  
Enzyme Substrate or target for enzyme degradation dotdot dot dot dotdotdot
Organic chemistry derivatization, including introduction of new functional groups   dotdot dotdot dotdotdot dotdot

dotdotdot Best product choice for listed ligand and target.
dotdot Alternative choice for listed ligand and target.
dot Can be used for listed ligand and target.
1 Dynabeads pre-coupled with streptavidin may be the best product choice.
2 Dynabeads M-450 Epoxy.
3 Dynabeads M-450 Epoxy are recommended for isolation, stimulation, and expansion of cells.
4 Bifunctional crosslinkers may be introduced to immobilize oligonucleotides onto the surface of Dynabeads Amine.

Surface-activated Dynabeads product list