A wide range of products—flexibility for your research

Invitrogen Surface-activated Dynabeads are available in different sizes, with a hydrophobic or hydrophilic nature, and with a variety of surface chemistries (see Table 1 below). To obtain the best possible results it is important to choose a size and surface of the Dynabeads suited for your application. The choice will depend on the nature of the ligand. In most applications several Dynabeads products can be used.

Antibodies or other ligands can be coupled onto the beads for affinity protein capture 
(click to enlarge).

Table 1. Choose the right surface-activated Dynabeads for your application.

Ligand Target Dynabeads Tosyl-
Dynabeads Amine Dynabeads Epoxy
Antibody Low MW antigen1 or peptide  dotdotdot dotdot dotdot dotdot
Protein or antibody dotdotdot dotdot dot dotdot
Protein complex
dot dot dotdotdot
Organelles dotdot     dotdot2
Phage1 dotdotdot dotdot dotdot dotdot
Virus dotdotdot dotdot dotdot dotdot
Bacteria dotdotdot dotdot    
Cells3 dotdotdot dotdot   dotdotdot
Antibody Fragment Phage1 or antibody dotdot dotdotdot dotdotdot dotdot
Protein Phage or carbohydrate dotdot dotdot dotdot dotdotdot
Nucleic acid dot dotdotdot dot dot
Peptide Phage1 or antibody dotdot dotdotdot dotdotdot dotdot
Carbohydrate Antibody   dot dotdotdot dot
Low MV antigen Antibody dotdot dotdot dotdot dotdot
Nucleic acids, oligonucleotide, aptamer, PNA Nucleic acid binding proteins1 dot dotdot dot4  
DNA1, RNA1 or PCR amplicons1   dotdotdot dot4  
Enzyme Substrate or target for enzyme degradation dotdot dot dot dotdotdot
Organic chemistry derivatization, including introduction of new functional groups   dotdot dotdot dotdotdot dotdot

dotdotdot Best product choice for listed ligand and target.
dotdot Alternative choice for listed ligand and target.
dot Can be used for listed ligand and target.
1 Dynabeads pre-coupled with streptavidin may be the best product choice.
2 Dynabeads M-450 Epoxy.
3 Dynabeads M-450 Epoxy are recommended for isolation, stimulation, and expansion of cells.
4 Bifunctional crosslinkers may be introduced to immobilize oligonucleotides onto the surface of Dynabeads Amine.

Surface-activated Dynabeads product list