The Invitrogen iBright Imaging Systems capture images and analyze data from your western blots and gels efficiently and easily. With a blend of modern design and performance, iBright Imaging Systems enhance your imaging workflow.

Instrument overview and how-to videos

Note that we make regular updates to instrument experience and function through firmware updates. The videos above accurately reflect the majority of instrument functions as featured, but some workflow and feature enhancements may not be reflected in these videos.

iBright Analysis Software how-to videos

Note that we've updated our iBright Analysis Software interface to further streamline the look and enhance the user experience. While there may be some differences in the visual elements of the iBright Analysis Software interface in these videos below, many of the functions and actions described are applicable to the current version of iBright Analysis Software.

1:00 – Brief overview of iBright Imaging Systems and iBright Analysis Software

4:40 – Gallery tab overview (importing images, gallery organization, adding and removing images from tray)

7:23 – Adjust tab overview (editing functions: crop, straighten, rotate, flip, invert, false color, contrast, show saturation)

19:15 – Analyze tab overview (automatic analysis, analysis frames, adding and removing bands from analysis, resizing band frames, molecular weight analysis, data table, auto-enhance, lane profile)

36:32 – Annotate tab overview (labeling images)

44:25 -  Generating and exporting an analysis report

47:42 – Image export 

51:30 – Renaming image files

52:15 – Question & answer session

1:10 – Overview of iBright Imaging Systems and considerations for achieving quantitative western blots

19:45 – Brief overview of Gallery tab functionality and image selection for analysis

21:45 – Brief overview of Adjust tab functionality

23:00 – Analyze tab (auto-analysis, lane and band adjustments)

26:30 – Normalization analysis with housekeeping proteins (HKPs)

31:30 – Background correction (local background correction, lane profile, and rolling ball background correction)

37:50 – Relative quantitation

39:30 – Total lane protein (TPN) normalization with No-Stain Protein Labeling Reagent

43:40 – Total lane protein (TPN) normalization “across the file” with membrane stain 

50:10 – Generating an image report

53:00 – Question & answer session

Scientist: Guillaume Pidoux
Location: France
Abstract: My group focuses on the spatiotemporal regulation of cAMP signaling in cardiac physiological and pathophysiological conditions.


The heart ensures that peripheral organs are perfused with blood and nutrients. Any alterations of this function lead to heart injury and failure. A-kinase anchoring proteins (AKAPs) are a family of scaffolding proteins that anchors protein kinase-A (PKA), and thus plays a central role in the regulation of cardiac function under physiological and pathological conditions.


We focus on understanding the direct role of AKAPs in cardiac physiology and during the occurrence of cardiomyopathies. We utilize molecular biology tools to direct shRNA mediated knockdown and reconstitution assays combined with biochemical assays (i.e., immunoblot, co-immunoprecipitation, TR-FRET and Alpha-Screen). We further support our studies with state-of-the-art confocal imaging (i.e., live-cell FRAP & FLIP, proximity ligation assay and super-resolution imaging).


Furthermore, we aim to develop protein-protein interactor (PPI) disrupting peptides to counteract anchored-PKA dependent cellular processes that are modified during cardiac pathologies. These specific PPIs could serve as new potential specific cardiac therapeutic agents.


Favorite feature of the iBright system: Easy-to-use interface allowing the acquisition of excellent resolution pictures.


Documentation and literature

Education and tools

Protein Electrophoresis and Western Blotting Education Center

Find the resources to succeed as you plan and perform your western blot experiments. Find detailed protocols, quick tips and tricks, how-to-videos, webinars and more.


Protein Electrophoresis and Western blotting Troubleshooting Guide  

Gaining publication quality results straightaway is not exactly the norm when performing western blotting- this guide provides step-by-step tips and tricks to obtain high-quality, publishable western results.

BlotBuilder Product Selection Tool

Get western blot solutions designed specifically for your target proteins and experimental needs. Use this tool to get a personalize western blot protocol.


Firmware and Software Updates

We regularly make firmware and software improvements for iBright Imaging Systems and iBright Analysis Software. To access the firmware and software updates and to review release notes, please visit our update page.




Find relevant citations from peer-reviewed journals where specific research results were generated using the iBright Imaging platforms.

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Title Year Category Subcategory
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Jung YH, et al. (2023) A conformation-selective protein binder for a KRAS mutant inhibits the interaction between RAS and RAF. Biochem Biophys Res Commun 645:110-117. 2023Structural biology/protein interactions
Wang W, et al. (2023) The impact of osmotic stresses on the biofilm formation, immunodetection, and morphology of Aeromonas hydrophila. Microbiol Res 269:127301. 2023Microorganisms and model organisms
Morales A, et al. (2023) PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells. J Gen Physiol 155(2):e202213180. 2023Cell signaling
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Kim YK, et al. (2023) Transcriptome Profile in the Mouse Brain of Hepatic Encephalopathy and Alzheimer's Disease. Int. J. Mol. Sci 24(1): 675. 2023Neurobiology
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van Vliet VJE, et al. (2022) Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. PLoS Pathog 18(12):e1011065. 2022Microorganisms and model organisms
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Park JH, et al. (2022) Protective Effects of Carnosol on Renal Interstitial Fibrosis in a Murine Model of Unilateral Ureteral Obstruction. Antioxidants 11(12): 2341. 2022Other
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Liu L, et al. (2022) Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway. Int Immunol 113: 109398. 2022Cell signaling
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Kim H, et al. (2022) Afrormosin exerts an anticancer effect via MAPK and AKT signaling pathways in B16F10 cells. Appl Biol Chem 65 71. 2022Cancer studiesSkin cancer
Song J, et al. (2022) Matrix Adhesiveness Regulates Myofibroblast Differentiation from Vocal Fold Fibroblasts in a Bio-orthogonally Cross-linked Hydrogel. ACS Appl Mater Interfaces 14(46):51669-51682. 2022Other
Xenias HS, et al. (2022) R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations. Commun Biol 5(1):1211. 2022Other
Benoit M, et al. (2022) Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation. Hum Mol Genet Nov 12 doi: 10.1093/hmg/ddac282.2022Other
Joo S, et al. (2022) α-ketoglutarate suppresses immediate early gene expression in cancer cells. Biochem Biophys Res Commun 637:144-152. 2022Cancer studiesGeneral
Jacob C, et al. (2022) Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension. J Biol Chem Nov 10 doi: 10.1016/j.jbc.2022.102691. 2022Other
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Kushwaha A, et al. (2022) Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone induces calcium signaling-dependent crosstalk between autophagy and apoptosis in human macrophages. Cell Signal 99:110441.2022Cell signaling
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Baglyas M, et al. (2022) High-performance thin-layer chromatography-antibacterial assay first reveals bioactive clerodane diterpenes in giant goldenrod (Solidago gigantea Ait.). J Chromatogr A July 9 doi: 10.1016/j.chroma.2022.463308. 2022Plant sciences
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Wu LK, et al. (2022) Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+ and MPTP induced Parkinson’s disease. Phytomedicine 104:154250. 2022Neurobiology
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Zhang K, et al. (2022) Sevoflurane attenuates hepatic ischemia reperfusion injury by the miR-122/Nrf2 pathway. Ann Transl Med 10(6):350. 2022Other
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Zhang X, et al. (2022) MiR-874-3p represses the migration and invasion yet promotes the apoptosis and cisplatin sensitivity via being sponged by long intergenic non-coding RNA 00922 and targeting Glycerophosphodiester Phosphodiesterase Domain Containing 5 (GDPD5) in gastric cancer cells. Bioengineered 13(3):7082-71042022Cancer studiesGastric cancer
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