PEGylation Reagents (PEG Labeling)

We offer activated linear and branched derivatives of polyethylene glycol (PEG) for pegylation and the PEG-modification of peptides and proteins via primary amines and sulfhydryl groups. These reagents are typically used to increase solubility, prolong stability, and reduce immunogenicity. Certain experimental systems and assay platforms depend on the ability to alter the mass, solubility or other properties of proteins, immunogens, reaction vessels and other materials.

Learn more about PEG labeling chemistries
Learn more about unreacted small molecule removal

Choose the right PEGylation reagent for your experiment

Reactive Chemistry/ GroupProductsSpacer Arm (Å)Pegylation application
Amine-reactive (NHS)MS(PEG)416.4ÅProtein or surface, terminating with a methyl group
MS(PEG)8  30.8Å
MS(PEG)1244.9Å
MS(PEG)2488.2Å
TMS(PEG)1277.5Å
Sulfhydryl-reactive (Maleimide)MM(PEG)1251.9ÅProtein or surface (branched), terminating with a methyl group
MM(PEG)2495.3Å
Carboxy-PEG-amine (Amine or carboxylic acid)CA(PEG)418.1ÅProtein or surface, terminating with a carboxylic acid or primary amine
CA(PEG)833.6Å
CA(PEG)1246.8Å
CA(PEG)2489.8Å
Carboxy-PEG-lipoamide (Bidentate thiol)CL(PEG)1256ÅGold or metal surface, terminating with a methyl group
Carboxy-PEG-thiol (Carboxylic acid or thiol)CT(PEG)1247.8ÅGold or metal surface, terminating with a carboxylic acid
Methyl-PEG-amine (Amine)MA(PEG)415.5ÅProtein, oxidized carbohydrate or surface, terminating with a methyl group
MA(PEG)829.7Å
MA(PEG)1243.9Å
MA(PEG)2486.1Å
Methyl-PEG-lipoamide (Bidentate thiol)ML(PEG)423.6ÅGold or metal surface, terminating with a methyl group
Methyl-PEG-thiol (Thiol)MT(PEG)415.8ÅProtein or inert material surface, terminating with a methyl group

Bulk or custom product request

Need larger quantities of our protein labeling, crosslinking or modification reagents? We offer bulk and custom fill sizes.

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