We offer activated linear and branched derivatives of polyethylene glycol (PEG) for pegylation and the PEG-modification of peptides and proteins via primary amines and sulfhydryl groups. These reagents are typically used to increase solubility, prolong stability, and reduce immunogenicity. Certain experimental systems and assay platforms depend on the ability to alter the mass, solubility or other properties of proteins, immunogens, reaction vessels and other materials.
Learn more about PEG labeling chemistries
Learn more about unreacted small molecule removal
Choose the right PEGylation reagent for your experiment
| Reactive Chemistry/ Group | Products | Spacer Arm (Å) | Pegylation application |
|---|---|---|---|
| Amine-reactive (NHS) | MS(PEG)4 | 16.4Å | Protein or surface, terminating with a methyl group |
| MS(PEG)8 | 30.8Å | ||
| MS(PEG)12 | 44.9Å | ||
| MS(PEG)24 | 88.2Å | ||
| TMS(PEG)12 | 77.5Å | ||
| Sulfhydryl-reactive (Maleimide) | MM(PEG)12 | 51.9Å | Protein or surface (branched), terminating with a methyl group |
| MM(PEG)24 | 95.3Å | ||
| Carboxy-PEG-amine (Amine or carboxylic acid) | CA(PEG)4 | 18.1Å | Protein or surface, terminating with a carboxylic acid or primary amine |
| CA(PEG)8 | 33.6Å | ||
| CA(PEG)12 | 46.8Å | ||
| CA(PEG)24 | 89.8Å | ||
| Carboxy-PEG-lipoamide (Bidentate thiol) | CL(PEG)12 | 56Å | Gold or metal surface, terminating with a methyl group |
| Carboxy-PEG-thiol (Carboxylic acid or thiol) | CT(PEG)12 | 47.8Å | Gold or metal surface, terminating with a carboxylic acid |
| Methyl-PEG-amine (Amine) | MA(PEG)4 | 15.5Å | Protein, oxidized carbohydrate or surface, terminating with a methyl group |
| MA(PEG)8 | 29.7Å | ||
| MA(PEG)12 | 43.9Å | ||
| MA(PEG)24 | 86.1Å | ||
| Methyl-PEG-lipoamide (Bidentate thiol) | ML(PEG)4 | 23.6Å | Gold or metal surface, terminating with a methyl group |
| Methyl-PEG-thiol (Thiol) | MT(PEG)4 | 15.8Å | Protein or inert material surface, terminating with a methyl group |
Bulk or custom product request
Need larger quantities of our protein labeling, crosslinking or modification reagents? We offer bulk and custom fill sizes.
Resources
For Research Use Only. Not for use in diagnostic procedures.
