Sulfhydryl-specific crosslinking reagents use maleimide or pyridyldithiol reactive groups for the selective covalent conjugation of protein and peptide thiols (reduced cysteines). These groups form stable thioether bonds, and are available in short, long, cleavable, and membrane permeable varieties.
We also offer BM(PEG)n crosslinkers at either end of a PEG2 or PEG3 spacer. PEG spacers provide unique advantages, including enhanced solubility, increased stability, reduced aggregation, and reduced immunogenicity.
|Reactive group||Products||Spacer Arm (Å)||Cleavable?||Water-soluble?||Membrane permeable?|
|TMEA (trifunctional)||10.3 Mid||No||No||Yes|
|DTME||13.3 Long||Yes, thiol||No||Yes|
For Research Use Only. Not for use in diagnostic procedures.