Ambion In Vivo siRNA molecules are chemically modified, 21-mer, double-stranded siRNAs that are recognized by the RNA-induced silencing complex (RISC) to mediate inhibition of a target gene. Proprietary chemical modifications allow Ambion In Vivo siRNAs to overcome many in vivo–specific obstacles, ensuring their effectiveness and stability in vivo. Ambion In Vivo siRNAs are at least 100x more stable in 90% mouse serum than unmodified siRNAs.

Ambion In Vivo siRNAs, the new standard for in vivo RNAi applications, offer:

  • High stability against nucleases
  • No induction of the interferon response
  • Easy tracking of administered siRNAs
  • Combined knockdown effectiveness and stability


Catalog # Purification Size
4457298 Standard Purity 5 nmol
4457302 HPLC purified 250 nmol
4457304 HPLC purified 1 umol
4457306 HPLC purified 10 umol
4457308 HPLC In Vivo Ready 250 nmol
4457310 HPLC In Vivo Ready 1 umol
4457312 HPLC In Vivo Ready 10 umol

Help Center

Order Support

Contact Order & Web Support, Search FAQs, View Order History and Track Your Order

Technical Support

Contact a Technical Application Scientist, Search Product Documents & FAQs and Instrument Maintenance & Repair Requests