Silencer® Select Pre-Designed & Validated siRNA
- Citations (9)
The Silencer® Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry. A choice of Silencer® Select siRNAs are available—Pre-Designed or Validated. Silencer® Select Pre-Designed siRNAs are guaranteed-to-silence based on their proven design while the Silencer® Select Validated siRNAs are functionally tested to reduce target gene expression. Sets of Silencer® Select siRNA Libraries are also available in tubes or plate for high throughput screening. The Silencer® Select Positive and Negative Control RNAs should be included in every siRNA experiment.
The benefits of using Silencer® Select siRNAs include:
- Potent—up to 100-fold more potent than currently available siRNAs and fewer off-target effects
- Most Specific—LNA® chemical modifications reduce off-target effects by up to 90%
- Reliable—demonstrated improvements in consistency and reliability of phenotypic results
- Guaranteed—100% guaranteed to silence, the best guarantee in the industry
Note: Silencer® Pre-Designed & Validated siRNAs are designed using our first-generation algorithm and DO NOT include any chemical modifications. They are recommended for completing in vitro RNAi studies that were started using Silencer® siRNAs. For new studies we recommend Silencer Select siRNAs.
Approximate Turnaround Times*
Standard purification: 4 business days
HPLC purification: 6 business days (20 and 40 nmol); 15 business days (250 nmol)
In Vivo Ready: 15 business days (250 nmol)
|4390817||Pre-designed||HPLC purified||20 nmol|
|4390818||Pre-designed||HPLC purified||40 nmol|
|4404014||Pre-designed||HPLC purified||250 nmol|
|4404010||Pre-designed||In Vivo Ready||250 nmol|
|4390815||Pre-designed non-inventoried||Standard purity||20 nmol|
|4390771||Pre-designed non-inventoried||Standard purity||5 nmol|
|4390816||Pre-designed non-inventoried||Standard purity||40 nmol|
|4392420||Pre-designed||Standard purity||5 nmol|
|4392421||Pre-designed||Standard purity||20 nmol|
|4392422||Pre-designed||Standard purity||40 nmol|
|4427037||Pre-designed||Standard purity||1 nmol|
|4390821||Validated||HPLC purified||20 nmol|
|4390822||Validated||HPLC purified||40 nmol|
|4407270||Validated||HPLC purified||250 nmol|
|4407267||Validated||In Vivo Ready||250 nmol|
|4390824||Validated||Standard purity||5 nmol|
|4390825||Validated||Standard purity||20 nmol|
|4390826||Validated||Standard purity||40 nmol|
|4427038||Validated||Standard purity||1 nmol|
*Estimated time from order confirmation to ship date from Austin, TX for orders confirmed by 2 pm CST. Does not include time required for shipping (typically overnight for US and Canada deliveries, 2 days for Europe, 2-3 days elsewhere).
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- Hardingham GE, Chawla S, Johnson CM, Bading H. (1997) Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression.Nature 385(6613):260–5.
- Zhu XD, Zhuang Y, Ben JJ, Qian LL, Huang HP, Bai H, Sha JH, He ZG, Chen Q (2011) Caveolae-dependent endocytosis is required for class A macrophage scavenger receptor-mediated apoptosis in macrophages. J Biol Chem 286(10):8231–9.
- Macheiner D, Gauglhofer C, Rodgarkia-Dara C, Grusch M, Brachner A, Bichler C, Kandioler D, Sutterlüty H, Mikulits W, Schulte-Hermann R, Grasl-Kraupp B (2009) NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A. Cancer Res 69(1):235-42.
- Vlotides G, Cooper O, Chen YH, Ren SG, Greenman Y, Melmed S (2009) Heregulin regulates prolactinoma gene expression. Cancer Res 69(10):4209-16.
For Research Use Only. Not for use in diagnostic procedures.