In mammalian cells the introduction of small 21–23 nucleotide sequence-specific RNA duplexes (small/short interfering RNAs, siRNAs) can act to initiate post-transcriptional gene knockdown and avoid triggering non-specific effects in mammalian cells (Figure 1). BLOCK-iT siRNAs are traditional, unmodified siRNA duplexes synthesized on demand with the highest quality. Using our award-winning BLOCK-iT RNAi Designer, you can design Custom BLOCK-iT siRNA sequences for any organism, using a cDNA sequence or a GenBank® accession number.
Custom BLOCK-iT siRNAs provide:
- The ability to custom design any number of siRNAs and controls
- High-quality, error-free siRNA duplexes
- A cost-effective approach for RNAi experiments
Figure 1. Typical siRNA duplex: 21 nucleotides long, with 2 DNA base-pair overhangs (TT).
For your convenience BLOCK-iT siRNAs can be ordered in 4 different synthesis scales. To design and order BLOCK-iT siRNAs, please visit the BLOCK-iT RNAi Designer.
For Research Use Only. Not for use in diagnostic procedures.