The Ion GeneStudio S5 Series is flexibly designed to enable a broad range of targeted NGS applications with industry-leading speed and scalability. Select from five different sequencing chips to sequence a throughput range from 2M to 130M reads per run. Simply choose the chip size and the instrument that matches your throughput and application needs.

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Meet the Ion GeneStudio S5 system

Which Ion GeneStudio S5 System is right for you?

Ion GeneStudio S5 System

Ion S5 and S5 XL NGS Sequencing Systems

Get started with targeted NGS

Ion GeneStudio S5 Plus System

Ion S5 and S5 XL NGS Sequencing Systems

Choose flexibility to support small and large projects

Ion GeneStudio S5 Prime System

Save time with greater throughput

Ion chip compatibility

Ion 510 Chip
Ion 520 Chip
Ion 530 Chip
Ion 540 Chip
Ion 510 Chip
Ion 520 Chip
Ion 530 Chip
Ion 540 Chip
Ion 550 Chip
Ion 510 Chip
Ion 520 Chip
Ion 530 Chip
Ion 540 Chip
Ion 550 Chip

Maximum throughput/day (chip type)

15 Gb (1 Ion 540 Chip)

30 Gb (2 Ion 540 chips)

50 Gb (2 Ion 550 chips)


19 hrs (Ion 540 Chip)

10 hrs (Ion 540 Chip)
11.5 hrs (Ion 550 Chip)

6.5 hrs (Ion 540 Chip)
8.5 hrs (Ion 550 Chip)

Learn about the simple workflow of the Ion GeneStudio S5 Series

Go ahead, ask.....

DNA to data with less than 45 minutes of hands-on time

With simple cartridge-loaded reagents and a straightforward user interface, the Ion GeneStudio S5 Series makes NGS fast and easy—ideal for any cancer or inherited disease research lab.

“The Ion Chef and S5 workflow is as simple as using a coffee pod machine but with espresso quality coffee.”

--Dr. Lesley Cheng, Postdoctoral researcher, Department of Biochemistry and Genetics, La Trobe University, Australia

Ion GeneStudio S5 Series targeted sequencing workflow

Total hands-on time: less than 45 minutes



  • Automated Ion AmpliSeq library protocols
  • Automated  template prep and chip loading


  • Ion GeneStudio S5 Series


  • Torrent Suite Software
  • Ion Reporter Software

Single sequencer.  Multiple applications.

The Ion GeneStudio S5 Series supports five different chip types, enabling different throughput and application needs. This flexibility also means you don't have to batch samples to achieve the optimum cost efficiency. Just choose the chip type that matches your specific throughput or application needs.

Learn more about NGS applications and see available app notes ›

Simple protocol. Same day results.

Get results in as little as 24 hours (with 2.5-4 hour sequencer run times) using the Ion GeneStudio S5 Prime System—the fastest turnaround of any benchtop sequencer.  Enjoy the simple protocol with load-and-go reagents and a straightforward user interface, allowing sequencer setup in less than 15 minutes of hands-on time. Add an Ion Chef System to your lab to benefit from automated library and template preparation.


Minimize sample input. Maximize flexibility.

Ion AmpliSeq technology enables successful library preparation from challenging sample types such as formalin-fixed, paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA (cfDNA) extracted from blood, using as little as 1 ng of input DNA or RNA to support multiple applications.

Learn more about Ion AmpliSeq technology ›

Go from DNA to variants in a few clicks

Torrent Suite Software and Ion Reporter Software make it easy for you to get started with your sequencing runs.  Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server).  Integrate, annotate, and interpret variants using Ion Reporter Software (cloud or local options available based on your needs). 

Learn more about NGS data analysis ›

Get expert answers. And peace of mind.

A global network of over 1,300 service and support personnel are dedicated to helping you maximize data integrity and instrument investment.  Through technical support, bioinformatics services, data storage, IT services, qualification services, application training, and optional extended warranty contracts, we can help provide peace of mind and increase laboratory productivity.

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