The Ion S5™ and Ion S5™ XL Systems enable massively parallel sequencing of hundreds to thousands of targeted genomic regions and multiple tumor research samples in one run. When combined with the Oncomine™ Comprehensive Assay and Ion AmpliSeq™ cancer research panels that make possible the survey of genes and genomic regions studied in cancer research, a high level of detection sensitivity can be achieved from a variety of samples such as fresh, frozen, or FFPE tissues. To get started, download the appropriate user guides from the table below.

Sequencing workflow for cancer research

Working with RNA? See RNA analysis with the Ion S5 System

Documents and resources


User guides and FAQs


Learn more

Training, events, and webinars