Gibco CTS Dynabeads T Cell Expansion Products
The first step in manufacturing an immunotherapy – autologous or allogeneic – is to collect peripheral blood mononuclear cells (PBMCs) from a patient (or donor for allogeneic). The cells then need to be isolated from the other mononuclear cells. Gibco CTS Dynabeads magnetic beads are a trusted technology for the isolation, activation, and/or expansion of T cells ex vivo. Whether working with polyclonal T cells, antigen-specific T cells, gene-modified T cells, regulatory T cells, or other T cell subtypes, CTS Dynabeads magnetic beads enable the recovery of T cells with properties comparable to in vivo–activated T cells. Select the correct Dynabeads magnetic beads for your specific work.
Gibco CTS Dynabeads T cell expansion product features:
- Suitable for the isolation, activation, and/or expansion of polyclonal T cells, antigen-specific T cells, gene-modified T cells, and other T cell subtypes
- Isolated and activated T cells help enable efficient gene transduction
- Expanded T cells have a T central memory phenotype with in vivo persistence
- Help deliver 100- to 1,000-fold expansion in 9–14 days
CTS Dynabeads CD3/CD28*
- CTS Dynabeads CD3/CD28 isolate CD3+ CD28+ T cells to high purity with high efficiency
- Isolated and activated CD4+ and CD8⁺ T cells expand 100- to 800-fold in 10 days while retaining a young phenotype (CD45RA+/– CD127+/– CD62L⁺ PD-1–)
- Expanded T cells have increased clonal diversity based on TCRβ sequencing
- Bead removal on day 2 improves transduction efficiency of a γ-retrovirus
- cGMP-compliant
CTS Dynabeads Treg Xpander*
- Aseptically manufactured and ready for clinical trials and cell therapy manufacturing process development
- Drug Master File (DMF) to cross-reference in IND applications
- >800-fold expansion after two stimulations
- Treg phenotype (FOXP3) and suppressive function maintained
- cGMP-compliant
Dynabeads Human T-Activator CD3/CD28*
- Activation of T cells without the need for feeder cells
- Activated cells that retain in vivo-like function
- Maximum reproducibility without contamination by soluble antibodies or mitogens
- From 100- to 1,000-fold T cell expansion
Application notes
Brochure
For Research Use Only. Not for use in diagnostic procedures.
