Cell Therapy Systems (CTS)

Scale-up to clinical and commercial manufacturing

Whether you’re developing an autologous or allogeneic T cell therapy, Gibco CTS OpTmizer serum-free media (SFM), created specifically for cell therapy, has been designed to help you scale-up to clinical and commercial manufacturing. With a proven track record, our media can help to minimize the risk of contamination and variability in your manufacturing and provide extensive traceability documentation including FDA Drug Master Files and Regulatory Support Files, helping to facilitate a seamless transition to commercialization.

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Gibco CTS OpTmizer media features:

  • Available in bottles and bags for use with closed, automated systems
  • Minimizes the need to purchase, store, and qualify serum, thus reducing variability and costs
  • Can enable more rapid T cell expansion, reducing cycle time and improving productivity
  • Complete serum-free, xeno-free medium, allowing for a seamless transition from research to clinical applications

CTS OpTmizer Pro SFM 

  • Maintains central memory T cells further into expansion and is well suited for longer workflows (>15 days)
  • Offers >90% (average) T cell fold expansion (from healthy donors) compared to CTS OpTmizer medium
  • Modest increases in central memory cells at early stage in expansion protocol result in larger cell yields at harvest
  • Helps achieve the same number of cells in a shorter duration
  • Ideally suited to the production of allogeneic therapies

CTS OpTmizer T-Cell Expansion SFM, no phenol red

  • Supports high-density T cell culture (>4 x 106 CD3+ T-cells/mL)
  • Supports T-cell activation using Dynabeads magnetic beads, soluble antibodies, and stimulatory antibody-presenting cell protocols
  • Demonstrates enhanced efficacy and persistence of CART-19 cells when grown in medium supplemented with CTS Immune Cell Serum Replacement (ICSR)
  • Widely adopted in clinical T-cell research applications including the culture of CAR T-cells

CTS OpTmizer T Cell Expansion SFM

  • Maintains similar phenotype and function (e.g., cytokine secretion profile) of polyclonally activated and cultured T cells as observed for conventional serum supplemented medium
  • Consistent performance in supporting T cell expansion
  • Complete serum-free, xeno-free medium, allowing for a seamless transition from research to clinical applications
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Related Resources

For Research Use Only. Not for use in diagnostic procedures.