Easy as 1-TO-3

Simplify the process with the TSQ Duo GC-MS/MS

Single quadrupole GC-MS has been around for years and has been the technology of choice for high-throughput, routine analyses for samples with relatively simple matrices. Triple quadrupole instruments are best suited for applications needing increased specificity, sensitivity, and/or the need to meet new regulatory requirements.

If you are contemplating the move from single quad to triple quad, you may be concerned with associated costs, ROI, and everything necessary for a successful transition: installation, training, method proficiency, and reporting. We can make the transition as Easy as 1-TO-3 with the Thermo Scientific™ TSQ™ Duo GC-MS/MS system and software tools.


Get easy access to powerful workflows through MS/MS, and satisfy current full scan (FS) and selected ion monitoring (SIM) method requirements. These capabilities are accomplished by the system’s excellent performance in both single and triple quadrupole modes, making it easily achievable, even for less experienced users.

For a limited time, take advantage of this “Easy as 1-to-3” special offer

 FREE  Thermo Scientific™ Chromeleon™ CDS software, 2nd year warranty, and on-site application support with the purchase of a new GC-MS/MS system.*

* Valid only in the United States and Canada.

Get more information ›

Simplify your transition from single to triple quadrupole technology with these 10 easy-to-use innovations

Feature Benefit Resources
TSQ Duo GC-MS/MS – Two Systems in One
  • Excellent performance in both single quadrupole and triple quadrupole scan modes.
  • In single quadrupole GC-MS mode, you can continue running your current set-up and established methods.
  • When the time is right, integrated software tools will walk you through a step-by-step process to manage the transition to powerful triple quadrupole methods.
Chromeleon CDS Software
  • Takes you from samples to results quickly and easily.
Method Portability
  • SIM Bridge is a method export tool for SIM to SRM methods.
  • Full MS and MS/MS method development even for the less experienced user.
Auto SRM
  • Fully integrated method development expert for optimized SIM target ions or SRMS transitions.
Timed SRM
  • Automated, intelligent tool for method optimization when your analyte list grows.
  • Use dwell time wisely for optimal sensitivity.
Gas Chromatograph Modularity
  • Guarantees flexible instrument configuration and less downtime.
  • Made possible by instant connect injectors and detectors that are user installable.
  • Part of the first and only truly modular GC with innovative and award winning technology that helps you be more agile.
Vacuum Probe Interlock
  • Wireless ion source removal without venting or cooling for nonstop productivity.
ExtractaBrite Ion Source
  • Requires less cleaning with robust, inert design that includes RF lens to protect quadrupoles from ion burn.
High-quality Support
  • Our center of excellence support experts are there when you need them.
Smarter, Optimized Workflows
  • Ultimate boost for your overall lab productivity from sample prep to reporting.

SIM Bridge: Simplifying the transition from single to triple quadrupole workflows

The TSQ Duo GC-MS/MS system is a unique instrument that can run single quadrupole selected ion monitoring (SIM) methods and then switch to triple quadrupole multiple/selected reaction monitoring (MRM/SRM) methods when the user is ready. This ability provides an easy transition for labs looking to make the jump from single to triple quadrupole methods. But what is behind this easy transition?

The answer lies in the power of the SIM Bridge tool and AutoSRM software, pioneered by Thermo Scientific™ technology for GC-MS/MS and included with the TSQ Duo GC-MS/MS system. Whenever you want to switch to MRM/SRM methods, SIM Bridge submits information from a SIM method to AutoSRM for easy, painless MS/MS method development.

AutoSRM is a mass spectrometer method development expert, integrated into the GC-MS/MS system. It walks you through development of fully optimized SRM transitions in a simple and efficient workflow.

Important resource:

See how these tools work in real applications:

Benefits of modularity

Modularity is your guarantee for a sustainable, robust workflow because it provides an extra layer of convenience, peace of mind, flexibility and unstoppable productivity. Quick customizations for GC and GC-MS workflows are now possible and without the need for a field service engineer. Your lab can now experience more uptime, quick customizations, faster recovery from scheduled preventive maintenance tasks, and greater flexibility when it comes to adding injectors, detectors, chemical ionization and direct insertion probes—important tools needed to meet the needs of all workflows.

  • GC instant connect injector and detector modules are user-installable in less than two minutes
    • Just remove three screws and put the new module in place
    • No special training, dedicated tools, or on-site service engineers required
  • Every GC injector and detector is self-sufficient
    • Contains the Integrated Electronic Gas Control (IEC)
    • Stores module calibration
  • Enable quick GC and/or GC-MS configurations
    • Simple and flexible configurations for evolving laboratory needs
      • GC injectors and detectors
      • Innovated MS source design
      • Easy vent-free MS source removal
    • Source cleaning without breaking vacuum
    • Switch from EI to CI without breaking vacuum
    • Probe analysis without modifying the GC and/or breaking vacuum
   Video: TRACE 1300 Series Gas Chromatograph
   Video: Vacuum Probe Interlock (VPI) (innovated ion source, CI and probes)
TSQ Duo Triple Quadrupole GC-MS/MS
TSQ 8000 EVO Triple Quadrupole GC-MS

Easy Vent-Free Source Removal on the Thermo Scientific ISQ GC-MS System
Innovative Thermo Scientific TRACE 1300 Series GC


Watch these informative webinars to learn more about how our instruments and software make the single quad to triple quad transition as easy as 1-to-3.

  • Making the GC-MS Transition with Ease
  • Future-Proofing Your GC-MS Analysis: Triple Quad Workflows on Demand
  • Pesticide Residue Analysis – The Fast and Easy Way
  • Meeting the New European Commission Regulations for Dioxin Detection and Confirmation Using GC-MS/MS

Looking for the next step up in triple quadrupole GC-MS/MS sensitivity, flexibility and productivity? The Thermo Scientific™ TSQ™ 8000 Evo Triple Quadrupole GC-MS/MS is the latest evolution that provides MS/MS simplicity and ultimate performance SRM. It has been designed and developed for high-throughput analytical laboratories. This unique system offers a harmonious combination of hardware and software features that help laboratories adapt to their changing environment and deliver quality results on time, every time.

Capability TSQ Duo TSQ 8000 Evo
Ionization EI only EI and CI-PCI, NCI & Combi
Vacuum Probe Interlock (VPI) No Yes
Scan Sensitivity
EI SRM 1 uL of 100 fg/uL OFN
≥6000:1 (Install Spec)
1 uL of 100 fg/uL OFN
≥12,000:1 (Install Spec)
Instrument Detection Limit - OFN ≤4 fg ≤0.5 fg
Collision Cell
MRM Speed 300 transition/sec 800 transition/sec
Minimum MRM Dwell 1.0 msec 0.5 msec
Scan Features
t-SRM Optional Yes
AutoSRM Yes Yes
Direct-Exposure No Yes
Direct-Insertion No Yes