Search Thermo Fisher Scientific
Achieve Tomorrow’s Quantitation with LC-MS Today
Tomorrow's quantitation provides certainty for complex analysis
Analytical demands are making quantitation more than just quantifying targeted analytes. Traditional quantitation was fueled by the knowledge of what compounds and/or contaminants were present in each sample. Scientists knew what they were testing and were able to rely on proven and well-tested technologies to quantify the target analytes. Today’s quantitation requires both qualitative and quantitative assessment. Screen, identify, and quantify more analytes than ever before with our LC/MS systems, which are ready for today's and tomorrow's quantitation needs. Because tomorrow's quantitation provides certainty for complex analysis today.
How can we answer your questions?
According to SDI’s Global Assessment 2018 report, quadrupole LCMS made up over one third of total mass spectrometry sales due to its wide usage in life science applications spanning pharmaceuticals, biotechnology, clinical research labs and academic research. However, the report expects to see fast growth in quantitative high-resolution mass spectrometry, such as quantitative Orbitrap and QTOF LCMS, as the demand for screening and quantitation of unknown compounds of interest continues to climb.
Maximize your return on investment in a unified Thermo Scientific mass spectrometry architecture from data acquisition and analysis solutions
Tomorrow's Quantitation Compendium
Developing robust quantitation assays is possible with both Triple Quadrupole and Orbitrap-based High- resolution MS instruments. Both technologies enable confident quantitation in a variety of sample types.
Thinking bigger by seeing smaller
Small molecules play a key role in our lives. Whether it is better understanding how our bodies interact with drugs, tracing the environmental fate of pesticides, developing new compounds, protecting brand reputations, or performing fundamental research, complete characterization, identification and quantitation of small molecules is an important task.
Find out which LCMS system might be right for you
The landscape for analytical laboratories is evolving; quantitation is not as straight forward as it was in the past. While triple quadrupole LCMS continues to be popular in industries associated with validated targeted quantitative methods, the pharmaceutical and biopharmaceutical laboratories are increasingly using quantitative high resolution accurate mass (HRAM) Orbitrap-based techniques to characterize their complex samples. Equally, over the next five years the applied segments (including food, clinical research, forensic toxicology and environmental testing) are expected to grow faster as concerns continue to arise to test for emerging compounds and contaminants; in a more efficient manner.
White paper: Which LC/MS system is right for you?
In this paper we outline the latest developments in Triple Quadrupole (QqQ) and Orbitrap-based high-resolution spectrometry, highlighting the suitability of each for varying application demands and challenges.
Orbitrap technology for quantitation, screening and confirmation
Discover how the power of Orbitrap mass analyzer technology delivers exceptional peak discrimination at low m/z, fine isotopic distribution, quantitation and unknown identification capabilities.
Transitioning to confident quantitation—in search of a better tomorrow
Dig deeper into the pros and cons of using LC-MS, both QqQ and HRAM-MS for quantitation compared to other traditional techniques. Learn about enhanced confidence and the ability to do more, more easily.
Advantages of HRAM and QqQ LC/MS technologies
The ability to develop robust and reliable assays with both triple quadrupole (QqQ) and high resolution accurate mass (HRAM) LC/MS systems has made these technologies a common choice when it comes to quantitation of analytes in complex matrices. Both QqQ and HRAM technologies offer unique advantages, enabling supreme confidence in the quantitation of a variety of molecule types.
| Needs | HRAM | QqQ |
|---|---|---|
| Untargeted screening |  |  |
| Targeted screening | | |
| Untargeted and targeted quantitation | |  |
| Targeted quantitation only | | |
| Retrospective analysis | | |
| = Not applicable |  = Poor |  = Good | = Better | = Best |
Which HRAM is right for you? Which QQQ is right for you? Which HPLC is right for you? Which IC is right for you?
How to select the most efficient approach for data acquisition and analysis
Taking qualitative discovery data from high-resolution systems, through to quantitation was traditionally a labour-intensive and manual process. Now, advancing screening through to quantitation is more streamlined and seamless than ever before. Data from studies using high-resolution MS systems can be easily interpreted with Thermo Scientific Compound Discoverer software, through the use of powerful data analysis tools and access to the World’s largest mass spectral fragmentation library mzCloud.
Once you’ve acquired the necessary insights and knowledge from your data, this can in-turn be easily transferred to generate routine quantitative and targeted screening workflows using either high-resolution or QqQ MS.
Which data analysis software is right for you?
| Needs | Compound Discoverer | TraceFinder | Chromeleon CDS |
|---|---|---|---|
| Untargeted, unknown screening (unknown knowns and unknown unknowns) | | | |
| Targeted screening (known unknowns) | | | |
| Untargeted and targeted quantitation | | | |
| Targeted quantitation only (known knowns) | | | |
| Complex targeted panel analysis | | | |
| GxP/21 CFR Part 11 compliance capable | | | |
| Library compatibility | | | |
| Thermo Scientific Chromatography and source compatibility | | | |
| Third Party Instrument Control | | | |
| = Not applicable | = Poor | = Good | = Better | = Best |
Customer and application spotlights
Case Study: Delivering a routine application for food, pharma and PCPs
Find out how Halvec Laboratories collaborated with Thermo Fisher Scientific to deliver an international reference method for gelatine analysis.
Latest mass spectrometry-based trends for identifying and quantifying unknown PFAS compounds
Emerging contaminants pose a significant analytical challenge: many compounds are complete unknowns. See how the latest MS hardware and software tools identify and quantify these “unknowns”.
Webinar: Expanded capabilities for bioanalysis, leveraging a CDS
Find out how bioanalytical workflows can be streamlined to increase productivity and optimize efficiency, without loss of compliance; even when implementing QqQ or HRAM MS.
Advances in Forensic Analyses: When to Use GC-MS/MS, LC-MS/MS, and HRAM
Find out about the clear benefits of these different technologies for forensic toxicology.
LC–MS workflows for veterinary drug testing laboratories
Learn how two different workflows, one QqQ and one HRAM MS, address the challenges faced within veterinary drug testing labs.
Biopharma: Targeted quantitation solution guide
When you need to deliver robust and reliable targeted quantitation for potentially complex samples, see how confident workflow solutions can meet your needs.
Related systems
Contact us
We’re here to help you maximize your free trial of TraceFinder software. Contact us if you would like more information on how to use it (or visit our support center), or if you would like to have a representative contact you.