Why choose Vanquish Duo HPLC and UHPLC systems?

Why choose Vanquish Duo HPLC and UHPLC systems?
  • Double sample throughput without changing validated methods
  • Increase output without sacrificing bench space
  • Improve return on investment by reducing cost per sample (Calculate your savings)
  • Achieve a new level of analytical precision with unsurpassed peak area and retention time precision
  • Get ideal fluidic connections with nearly-zero dead volume Thermo Scientific Viper fingertight fittings
  • Control your system with the industry-leading, easy-to-use and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools

Vanquish Duo UHPLC Systems for Dual LCVanquish Duo UHPLC Systems for Dual LC-MSVanquish Duo HPLC and UHPLC Systems for Tandem LC or LC-MSVanquish Duo HPLC and UHPLC Systems for Inverse Gradient
Benefit
Doubled productivity with 2 independent UHPLC channels built into one stackIntegrated multi-channel LC for ultra-high-throughput LC-MSMaximized detector utilization by using offline column reconditioningUniform Response with charged aerosol detection
Supported systems
Vanquish Flex
Vanquish Horizon  
Vanquish Flex
Vanquish Horizon  
Vanquish Core
Vanquish Flex
Vanquish Horizon  
Vanquish Core
Vanquish Flex
Vanquish Horizon  
Applicable autosampler
Dual split samplerDual split samplerSplit samplerSplit sampler
Common detector setup
1-2 detectors per channel
(2-4 detectors per system)
1 mass spectrometerUp to 2 detectors and/or 1 mass spectrometer1 Vanquish Charged Aerosol Detector at a minimum
Software control
Thermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Waters™ Empower™ 3 CDS softwareThermo Scientific Aria MX softwareThermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Thermo Scientific XCalibur softwareThermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Waters™ Empower™ 3 CDS software

Double your throughput, deepen your sample knowledge and better utilize your bench space with the Vanquish Duo UHPLC System for Dual LC workflows, a two channel LC, for improved return on investment. By using two pumps and a unique Vanquish Dual Split Sampler this single instrument can run 2 analysis simultaneously, no matter if identical or different analysis are desired.

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time savings when running two different assays on the Vanquish Duo for Dual LC simultaneously

Illustration of the time savings when running two different assays on the Vanquish Duo for Dual LC simultaneously, compared to the time required to run the same two assays on a traditional single channel HPLC system.

Double the throughput of your LC-MS application with the Vanquish Duo for Dual LC-MS. Run up to two applications simultaneously with a multi-channel LC while benefiting from the robustness, performance and ease of use built into the Vanquish platform.

The Vanquish Duo system for Dual LC-MS is a multichannel LC system designed specifically for LC-MS. This system utilizes Thermo Scientific Aria software to optimize performance and productivity by controlling pump operation, injection, valve switching, cleaning, and gradient procedures to ensure the mass spectrometer is never idle.

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Multichannel LC-MS Method

Illustration of the resulting MS signal when running two different applications on a multichannel LC-MS system simultaneously.

Learn how the Vanquish Duo for Dual LC-MS increases your metabolome coverage and sample throughput for your metabolomics experiments

Increase your lab's throughput and return on investment with the Vanquish Duo HPLC and UHPLC Systems for Tandem LC or LC-MS, instruments for offline column regeneration, to efficiently use your detector or mass spectrometer and maximize the output.

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Standard LC LC-MS Tandem LC LC-MS

Symphogen testimonial on how to accelerate result generation for Lead Selection Studies through MS utilization with Vanquish Duo Tandem LC Workflow

Improve your lab's quantification capabilities with the Vanquish Duo for Inverse Gradient, employing unique and universal charged aerosol detection to quantify all non-volatile and semi-volatile compounds, even when no reference standard is available.

Changing organic composition over a gradient elution results in fluctuation in analyte response. Post column application of an inverse gradient compensation eliminates this effect by ensuring the eluent entering the detector always has the same solvent composition regardless of where the compound elutes during the gradient separation.

Consistent charged aerosol detector response means that unknown substances can be quantified, even if you lack an individual standard of a specific compound.

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Standard LC Inverse Gradient Method

Illustration of how an inverse gradient is applied to mitigate varying organic composition effects on charged aerosol detector response.

This whiteboard video describes the fundamental principles of charged aerosol detection and explains how a sample travels through the detector.

Vanquish Duo HPLC and UHPLC learning materials

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Style Sheet for Global Design System