Why choose a Vanquish HPLC or UHPLC system?

Vanquish HPLC and UHPLC systems offer:

  • A broad range of instruments to serve every analytical need, from small to large molecules, from complex to simple mixtures
  • Innovative technology, intuitive operation, and easy maintenance
  • Analytical precision, including unsurpassed peak area and retention time precision
  • Ideal fluidic connections with nearly-zero dead volume Thermo Scientific Viper fingertight fittings
  • Convenient instrument control with the easy-to-use and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools
  • Instrument control of Vanquish Horizon and Vanquish Flex UHPLC systems under Waters Empower 3 CDS software with Thermo Scientific Standard Instrument Integration (SII)
Vanquish HPLC and UHPLC Systems

Learn how revolutionary HPLC technology from Thermo Fisher Scientific has changed and improved the science of HPLC over the last 35+ years.

Meet the Vanquish HPLC and UHPLC systems

Choose from these three modular systems to meet your analytical and performance requirements. In addition to these base systems, we offer several application-specific systems that are individually configured from the modules of these systems.

Vanquish Core HPLC Systems
Vanquish Core HPLC Systems
Vanquish Flex UHPLC Systems
Vanquish Flex UHPLC Systems
Vanquish Horizon UHPLC Systems
Vanquish Horizon UHPLC Systems
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Typical applications
Achieve dependable traditional or routine HPLC analysis with Vanquish Core HPLC systems. These systems remove disruptions to your analyses and empower operators to deliver continuous results. Regardless of the systems your laboratory currently uses, switching to the Vanquish Core HPLC is simple and seamless. Gain the flexibility to run both HPLC and UHPLC on a single system with Vanquish Flex UHPLC systems. These systems offer flexible method development to accommodate all applications. Vanquish Flex UHPLC systems offer outstanding performance for targeted UHPLC and LC-MS workflows. Get top performance and resolution for demanding separations with the Vanquish Horizon UHPLC systems. These systems provide unrivaled performance and throughput for your most complex and difficult samples. They allow for smaller particles and column dimensions to be run with greater confidence for the most demanding UHPLC and LC-MS workflows.
Pump options Pump options Pump options
Binary, Quaternary, Dual and Isocratic Binary, Quaternary and Dual Binary
System pressure System pressure System pressure
Half circle
Up to 700 bar
3/4 circle
Up to 1000 bar
Full circle
Up to 1500 bar
Retention time precision
3/4 circle 3/4 circle Full circle
Flow range
Full circle
10 mL/min
Full circle
8 mL/min
3/4 circle
5 mL/min
Biocompatible
No Yes Yes

 

Application-specific LC systems

In addition to our three base systems, the modules from the Vanquish Core, Vanquish Flex and Vanquish Horizon systems can be individually configured to create systems for specific applications. We offer several application-specific HPLC and UHPLC systems for applications ranging from dual LC and LC-MS to those featuring online sample preparation or heart-cutting 2D-LC workflows. These modular systems can be individually configured using Vanquish Core HPLC, Vanquish Flex UHPLC or Vanquish Horizon UHPLC components.

  Systems built from Vanquish Core HPLC components Systems built from Vanquish Flex UHPLC components Systems built from Vanquish Horizon UHPLC components
Vanquish Duo for Dual LC   checkmark checkmark
Vanquish Duo for Dual LC-MS   checkmark checkmark
Vanquish Duo for Tandem LC or LC-MS checkmark checkmark checkmark
Vanquish Duo for Inverse Gradient LC checkmark checkmark checkmark
Vanquish Online SPE Systems checkmark checkmark checkmark
Vanquish Loop Heart-Cut 2D-LC Systems checkmark checkmark checkmark
Vanquish Trap Heart-Cut 2D-LC Systems   checkmark checkmark
Vanquish Simple Switch 2D-LC Systems   checkmark checkmark

Vanquish Duo UHPLC Systems

Increase your productivity, system up-time, and sample knowledge for a faster return on investment with the Vanquish Duo HPLC and UHPLC systems. These systems expand the benefits of the Vanquish platform with four workflows (Dual LC, Tandem LC or LC-MS, Dual LC-MS, and Inverse Gradient LC). Each Vanquish Duo HPLC or UHPLC system features an independent separate second flow path within the integrated system allowing you to save time and cost per sample with no need for additional bench space, and without compromising performance, robustness, or ease of use.

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Vanquish Online 2D-LC Systems

Add more separation power and gain more confidence in your sample analysis using 2D-LC (LC-LC). Four different Vanquish Online 2D-LC systems enable online sample preparation, multiple heart-cutting modes and even include a system that offers the flexibility to switch between gaining the confidence of 2D-LC and the productivity of Dual LC. All four Vanquish Online 2D-LC systems allow you to explore your sample in depth.

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Vanquish HPLC and UHPLC learning materials

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