Introducing the Ion GeneStudio S5 Series next-generation sequencers

Single sequencer. Multiple applications. Now more scalable than ever.


Yes, with the Ion GeneStudio S5 Series flexible chip format, your research accelerates across both small and large projects without the need to change instruments. The fast, automated workflow achieves sample to answer results across a broad range of applications.

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  • Speed
  • Scalability
  • Simplicity
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  • Small sample input
  • Minimal hands-on time

Meet the Ion GeneStudio S5 systems

Five Ion 5 Series chips

Figure 1. Five Ion 5 Series chips achieve 2–130M reads per run to enable a broad range of applications. Reads per run shown are maximum reads per chip

Learn more about Ion GeneStudio S5 Series sequencing ›

Featured research applications



Highly-referenced, single-platform solutions enabling low- and ultra-low sample inputs to comprehensively profile even the most challenging FFPE, liquid biopsy and immuno-oncology research samples.

Inherited disease

Inherited disease

Fixed, Made-to-Order, and On-Demand Ion AmpliSeq panels help you discover causal variants easily with a simple and fast Ion GeneStudio S5 sequencing workflow with nucleic acid-to-answer automation.

Microbial and infectious diseases

Microbial and infectious diseases

A flexible chip format enables you to cost-effectively process samples without batching—explore species diversity and abundance with the higher dynamic range achieved by the Ion GeneStudio S5 Series.

RNA applications

RNA applications

The Ion GeneStudio S5 Series enables applications from mRNA gene expression profiling to whole transcriptome sequencing.

Ion AmpliSeq HD technology

Coming soon! Ion AmpliSeq HD technology

Achieve ultralow frequency variant detection from both liquid biopsy and FFPE research samples with a new innovation in library preparation, Ion AmpliSeq HD technology—available later this year.

Fast results. Consistent answers. Sample to answer automation.

New Ion 550 Chip enables speed and flexibility with excellent data quality

“Exome trios are straightforward in a single Ion 550 chip run. We’ve also run mouse transcriptome, DNA and RNA panels. Data quality is excellent; comparable with our Ion 540 chip data.”

—Adam Ameur, Genome Center, University of Uppsaala, Sweden
“We have already adopted the new chip in our workflows so that we can gain significant time and cost advantages.”

—Inger Jonasson, Department of Immunology, Genetics and Pathology, University of Uppsala, Sweden