Conventional models of one-drug-one-disease are changing fast. Genetic research is at the forefront, fueling new discoveries that link diseases, therapies, and patient responses. Thermo Fisher genetic analysis solutions are helping to rapidly drive connections for multi-therapeutic approaches to treat complex human diseases.

When you partner with us on your journey from discovery to manufacturing you gain access to a breadth of technologies that enables to you to keep up with the development pace of therapeutics, interventions, and vaccines.

Download whitepaper “QC for ex vivo manipulated cell lines and tissues”

 Discovery

 Screening and optimization

 Process development

 Clinical trials

 Manufacturing

genetic-analysis-infographic22
Learn how genetic advancements can help to speed potential therapeutics to market


What's New?

jingfang-ju-phd

miRNA-based biomarkers and therapeutics for cancer

In this conversation with Dr. Jingfang Ju, he discusses advances in developing miRNA-based therapeutics and the value of gene expression analysis in discovering and verifying new miRNA-based biomarkers.

Download spotlight ›
QC-ex-vivo-manipulated-cell-lines-tissues-grey

QC for ex vivo manipulated cell lines and tissues

A variety of genetic analysis methods are valuable in ensuring that ex vivo human cells to be used for cell-based therapies are correctly identified, have the correct characteristics, and are free of contaminants.

Download whitepaper ›

 

darren-roberts-phd

Transcriptome analysis in tumors and response to therapy

In this conversation with Dr. Darren Roberts, he discusses challenges in conducting gene expression studies with DNA and RNA from  FFPE tumor tissues. He also explains the importance of selecting the right technology for each sample and stage in the process.

Download spotlight ›


Discovery

target-identification-pod1

Target identification

Drive new approaches to therapeutic development based on the impact of genetic and epigenetic targets on disease pathogenesis.

Gene expression analysis

Identify new potential genetic targets for your discovery of promising therapeutics by exploring genetic variability among influential biomarkers.

  • TaqMan Fast Advanced Master Mix
    Designed to match or exceed the performance of standard master mixes, delivering shorter run times (<40 minutes) with results equal to or better than what is achieved today.
Biomarker-discovery-pod2

Biomarker discovery

Propel studies of factors of prognostic risk, therapeutic response, and disease heterogeneity that may be influenced by genetic markers.

Gene sequencing

Confirm the identity of biomarkers associated with genetic response to your biopharmaceutical with confidence in confirmed sequences from gene editing, next-generation sequencing, and detection of low-level variants.

  • Sanger sequencing
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 

Single gene expression analysis

Focus your discovery of new biomarkers through exploration of the impact of your biopharmaceutical on key identified genes.

  • TaqMan individual expression assays
    Designed to detect virtually any gene transcript, with more than 2.8 million predesigned assays
  • TaqMan Fast Advanced Master Mix
    Designed to match or exceed the performance of standard master mixes, delivering shorter run times (<40 minutes) with results equal to or better than what is achieved today.

Expression signature analysis

Investigate the potential interrelationships of complex biomarker interactions from splice isoforms and non-coding transcripts throughout the complete transcriptome.

miRNA analysis

Reveal new potential regulatory associations with response to your biopharmaceutical through discovery, isolation, and characterization of miRNA markers.

  • TaqMan miRNA assays
    Innovative tools for miRNA research—from isolation through discovery, profiling, quantitation, validation and functional analysis.
Pathogen-characterization-pod2

Pathogen characterization

Uncover potential drivers of drug resistance and virulence from within microbial and viral strain genomes.

LOD testing

Uncover and characterize the genetic impact of low levels of pathogen exposure with confidence.

  • TaqMan individual expression assays
    Designed to detect virtually any gene transcript, with more than 2.8 million predesigned assays
  • TaqMan gene expresson panels
    Gold-standard specificity, sensitivity, and reproducibility. Ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets.
  • TaqMan Fast Advanced Master Mix
    Designed to match or exceed the performance of standard master mixes, delivering shorter run times (<40 minutes) with results equal to or better than what is achieved today.

Pathogen gene and genome sequencing

Identify, distinguish, and confirm strain lineages of the pathogen targets of your biopharmaceutical based on gene dropouts, deletions, and variants.

  • Sanger sequencing
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 

Pathogen transcript analysis

Detect fastidious organisms and poly-microbial or poly-syndromic infection quickly and culture-free.

  • Taqman custom assays
    The custom version of our predesigned real-time PCR 5' nuclease TaqMan assays for relative quantification of RNA expression.
  • TaqMan Fast Advanced Master Mix
    Designed to match or exceed the performance of standard master mixes, delivering shorter run times (<40 minutes) with results equal to or better than what is achieved today.

16S gene sequencing

Investigate varying responses of different pathogens to your biopharmaceutical through genetic identification of microbial strains.

  • Sanger sequencing
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 
pathogen-interactions-pod2

Host/pathogen interactions

Explore the genetics and epigenetics that govern pathogenesis, cell tropism, and host immune response to pathogen invasion.

Host gene expression analysis

Explore the impact of your biopharmaceutical on host susceptibility to viral entry, tropism, and transmission through key gene expression pathways and networks.

  • TaqMan individual expression assays
    Designed to detect virtually any gene transcript, with more than 2.8 million predesigned assays
  • TaqMan gene expresson panels
    Gold-standard specificity, sensitivity, and reproducibility. Ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets.
  • TaqMan Fast Advanced Master Mix
    Designed to match or exceed the performance of standard master mixes, delivering shorter run times (<40 minutes) with results equal to or better than what is achieved today.

Pathogen gene expression

Explore the potential impact of host phenotypes on the expression of pathogen genes.

  • TaqMan custom assays
    The custom version of our predesigned real-time PCR 5' nuclease TaqMan assays for relative quantification of RNA expression.
  • TaqMan pathogen detection assays
    Designed to detect virtually any gene transcript, with more than 2.8 million predesigned assays
  • TaqMan Fast Advanced Master Mix
    Designed to match or exceed the performance of standard master mixes, delivering shorter run times (<40 minutes) with results equal to or better than what is achieved today.

Host sensitivity genotyping

Investigate differences among individuals regarding disease susceptibility, severity, and outcome associated with your biopharmaceutical.

  • Axiom genotyping microarrays
    The platform of choice for large-scale genotyping studies.
  • TaqMan genotyping assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples.
  • Sanger sequence confirmation
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 


Screening and optimization

 

High-throughput-screening-pod1.jpg

High-throughput screening

Speed through large combinatorial plasmid, CRISPR, and fragment libraries to screen for desired drug target variants.

High throughput expression analysis

Streamline exploration of large libraries of constructs to explore genetic variants associated with genetic regulation of and response to your biopharmaceutical.

  • Custom OpenArray plates
    Five customizable formats give you unmatched flexibility to select from over 61,000 inventoried TaqMan Gene Expression Assays to be pre-loaded onto OpenArray Plates. 
  • Custom TaqMan plates and array cards
    Customized cards and plates allow you to configure your panel from scratch choosing from any of our 2.8 million predesigned TaqMan Gene Expression Assays. 
  • TaqMan Fast Advanced Master Mix
    Designed to match or exceed the performance of standard master mixes, delivering shorter run times (<40 minutes) with results equal to or better than what is achieved today.

Expression vector sequencing

Quickly verify your large libraries of knock-in, knock-out, indel, and variant constructs with rapid sequencing of gRNA, transfection vectors, and recombinant gene assemblies.

  • Sanger plasmid/vector sequencing
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 
Target-validation-disease-modeling-pod

Target validation and disease modeling

Transform development of new therapeutic approaches with gene knock-down and knock-up investigations.

Sequence confirmation of genome edits

Optimize performance of your gene editing workflows with validated indels and variants.

  • Sanger sequencing primary/secondary edits
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 
  • TaqMan genotyping assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples

Gene expression change confirmation

Confirm the gene expression changes that you intend from edits to biomarkers associated with your biopharmaceutical.

Pathogen detection

Validate the impact of your biopharmaceutical on key biomarkers by exposing the identity, and expression of pathogen genes in infected hosts.

  • TaqMan genotyping  assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples.
  • Custom fragment analysis panels
    Analysis of DNA fragments enables a variety of applications, from cell line authentication to detection of aneuploidy. 

Biomarker analysis

Characterize influential biomarkers based on genome modification in disease model systems relevant to your biopharmaceutical.

  • TaqMan miRNA assays
    Innovative tools for miRNA research—from isolation through discovery, profiling, quantitation, validation and functional analysis.
  • TaqMan Fast Advanced Master Mix
    Designed to match or exceed the performance of standard master mixes, delivering shorter run times (<40 minutes) with results equal to or better than what is achieved today.
  • Custom TaqMan array plates or cards
    Customized cards and plates allow you to configure your panel from scratch choosing from any of our 2.8 million predesigned TaqMan Gene Expression Assays. 
Preclinical-dosage-toxicology-safety-testing-pod

Preclinical dosage, toxicology, and safety testing

Accelerate vital studies to identify impacts of treatment on gene expression in animal models.

Tissue damage gene expression

Assess the genetic impact of your biotherapeutics on target and off-target tissues.

Drug metabolizing enzyme gene expression

Investigate changes in expression of genes associated with absorption, distribution, metabolism, and excretion of your biopharmaceutical.

  • TaqMan off-the-shelf expression panels
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets

  • TaqPath qPCR Master Mixes
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets. 
  • Pharmacoscan microarrays
    Allow clinical researchers to gain valuable insight into an individual’s ability to process drugs known to be clinically actionable based upon high, moderate, low, and preliminary scientific evidence.

Gene expression analysis

Reveal potential genetic toxicity of your biopharmaceutical through expression analysis of target genes.

Pathogen detection

Determine the effectiveness of medication dosage to reduce expression of pathogen genes in the host.

  • TaqMan genotyping assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • Custom fragment analysis panels
    Analysis of DNA fragments enables a variety of applications, from cell line authentication to detection of aneuploidy. 
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples.
High-throughput-screening-pod1

High-throughput screening

Speed through large combinatorial plasmid, CRISPR, and fragment libraries to screen for desired drug target variants.

High throughput expression analysis

Streamline exploration of large libraries of constructs to explore genetic variants associated with genetic regulation of and response to your biopharmaceutical.

  • Custom OpenArray plates
    Five customizable formats give you unmatched flexibility to select from over 61,000 inventoried TaqMan Gene Expression Assays to be pre-loaded onto OpenArray Plates. 
  • Custom TaqMan plates and array cards
    Customized cards and plates allow you to configure your panel from scratch choosing from any of our 2.8 million predesigned TaqMan Gene Expression Assays.
  • TaqPath qPCR Master Mixes
    Designed to match or exceed the performance of standard master mixes, delivering shorter run times (<40 minutes) with results equal to or better than what is achieved today.

Expression vector sequencing

Quickly verify your large libraries of knock-in, knock-out, indel, and variant constructs with rapid sequencing of gRNA, transfection vectors, and recombinant gene assemblies.

  • Sanger plasmid/vector sequencing
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 


Process development

 

Microbial-identification-pod1

Microbial identification

Streamline development of new approaches to testing for microbes and mycoplasma.

16S gene sequencing

Assess effective exclusion of microbial contamination from your biopharmaceutical sample preparations rapidly and without cell culture.

  • MicroSeq solution
    Combines the benefits of PCR and DNA sequencing technologies to enable highly accurate results.
  • Sanger sequencing
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 

Mycoplasma detection

Assess effective exclusion of mycoplasma from your cell cultures rapidly and without cell culture.

  • TaqMan mycoplasma detection assays
    Designed to detect virtually any gene transcript, with more than 2.8 million predesigned assays
  • TaqPath qPCR Master Mixes
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets. 
  • Custom fragment analysis panels
    Analysis of DNA fragments enables a variety of applications, from cell line authentication to detection of aneuploidy. 

Targeted organism detection

Identify contamination from specific microbial strains in cell cultures for biopharmaceutical research.

  • TaqMan genotyping  assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • Custom TaqMan assays
    The custom version of our predesigned real-time PCR 5' nuclease TaqMan assays for relative quantification of RNA expression. 
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples.
Biological-sample-collection-pod

Biological sample collection, storage, and quality control

Ensure the integrity of cell lines for biotherapeutic studies.

Input sample identity cataloging, tissue archive authentication, and donor/host compatibility

Authenticate the genetic identity and purity of your cell cultures in storage.

  • Identifiler CLA kits
    Optimized to analyze 16 highly variant human STRs over a wide range of purified gDNA preparations 
  • Globalfiler CLA kits
    Allows 6-dye analysis of 24 loci, 16 of which are included in the Identifiler kits.
Residual-vector-quantification-pod

Residual vector quantification

Drive studies of the impact of residual impurities and antibiotic resistance genes to assess quality and safety of biotherapeutics.

Sequence detection

Identify residual plasmid DNA in your cells and tissues for gene therapy, cell therapy, and vaccine production research.

  • Sanger sequencing reagents
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 
  • Custom TaqMan assays
    the custom version of our predesigned real-time PCR 5' nuclease TaqMan assays for relative quantification of RNA expression. 
  • TaqPath qPCR Master Mixes
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets. 

Quantitative dPCR

Quantify absolute viral vector titers in your cell cultures determine concentrations of your biotherapeutic for use in gene and cell therapies.

  • Custom TaqMan dPCR assays
    A powerful yet easy-to-use digital PCR experience through its unique Microfluidic Array Plate (MAP) technology.
  • QuantStudio Absolute Q dPCR System
    A plate-based digital PCR (dPCR) platform that enables all the necessary steps for dPCR—compartmentalizing, thermal cycling, and data acquisition—to be conducted on a single instrument.

 



Cell-line-quality-control-pod

Cell line quality control

Speed development of new approaches to cell-based therapeutics with authenticated cell lines and known sources of potential contamination.

STR matching

Confirm the identity of your human cultured cells with confidence.

  • Identifiler CLA kits
    Optimized to analyze 16 highly variant human STRs over a wide range of purified gDNA preparations 
  • Globalfiler CLA kits
    Allows 6-dye analysis of 24 loci, 16 of which are included in the Identifiler kits.

Mycoplasma detection

Assess effective exclusion of mycoplasma from cell cultures for biopharmaceutical research rapidly and without cell culture.

  • TaqMan mycoplasma detection assays
    Designed to detect virtually any gene transcript, with more than 2.8 million predesigned assays
  • TaqPath qPCR master mixes
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets. 
  • Custom fragment analysis panels
    Analysis of DNA fragments enables a variety of applications, from cell line authentication to detection of aneuploidy. 

Expression system sequence integrity

Verify your isolated RNA sequences for integrity and purity for Northern analysis, cDNA library construction, and microarray analysis.


Clinical trials

Therapeutic-efficacy-assessmentjpg

Therapeutic efficacy assessment

Transform possibilities for therapeutic efficacy assessment based on potential impacts of gene expression and pathogen invasion.

Pathogen detection

Detect the presence and expression of pathogen genes within control, infected, and treated subjects for your clinical trial research.

  • TaqMan genotyping assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples.
  • Custom fragment analysis panels
    Analysis of DNA fragments enables a variety of applications, from cell line authentication to detection of aneuploidy. 

Biomarker confirmation

Ensure your biotherapeutics are acting upon the intended markers and genes.

  • TaqMan miRNA assays
    Innovative tools for miRNA research—from isolation through discovery, profiling, quantitation, validation and functional analysis.
  • Custom TaqMan array plates or cards
    Customized cards and plates allow you to configure your panel from scratch choosing from any of our 2.8 million predesigned TaqMan Gene Expression Assays. 
  • TaqPath qPCR master mixes
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets. 
Toxicology-safety-assessment

Toxicology and safety assessment

Drive studies to reveal impacts of dosing, biotherapeutics, or multi-drug therapies on gene expression.

Tissue damage gene expression

Assess the genetic impact of your biopharmaceutical tests on target and off-target tissues.

  • TaqMan off-the-shelf expression panels
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets.
  • Custom TaqMan expression panels
    The custom version of our predesigned real-time PCR 5' nuclease TaqMan assays for relative quantification of RNA expression.
  • TaqPath qPCR master mixes
    Validated to deliver exquisite lot-to-lot reproducibility for absolute Ct consistency and dynamic range across a wide variety of assays and applications.

Drug metabolizing enzyme gene expression

Detect the impact of your biopharmaceutical tests on expression of genes associated with drug absorption, distribution, metabolism, and expression.

  • TaqMan off-the-shelf expression panels
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets.
  • TaqPath qPCR master mixes
    Validated to deliver exquisite lot-to-lot reproducibility for absolute Ct consistency and dynamic range across a wide variety of assays and applications.
  • Pharmacoscan microarrays
    Allow clinical researchers to gain valuable insight into an individual’s ability to process drugs known to be clinically actionable based upon high, moderate, low, and preliminary scientific evidence.
people-bkg-pod

Population stratification

Explore variability in responses to treatments, differentiate genetic vs. lifestyle contributors to disease, and investigate biomarkers for personalized therapies.

Genotypic stratification

Characterize and differentiate genetic variability in susceptibility, severity, and outcome for target diseases within your population cohort.

  • Axiom genotyping microarrays
    The platform of choice for large-scale genotyping studies.
  • TaqMan genotyping assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples.

Pharmacogenetic characterization

Characterize responses to your biopharmaceutical based on gene expression across your population cohort.

  • OpenArray Pharmacogenetic panels
    Deliver a sample-to-answer workflow that allows you to introduce pharmacogenomic testing into your laboratory with ease.
  • Pharmacoscan microarrays
    Allow clinical researchers to gain valuable insight into an individual’s ability to process drugs known to be clinically actionable based upon high, moderate, low, and preliminary scientific evidence.

Companion diagnostic screening

Link individual variability in phenotypic response to your biopharmaceutical through identification of associated genetic biomarkers.

  • TaqMan genotyping assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples.
Pharmacogenetic-screening_bkgrnd

Pharmacogenetic screening

Inspire new approaches to assessment of variability among drug metabolism genes and the relationships between genetic variations and drug response.

Pharmacogenomic profiling

Reveal individual variability in response to your biopharmaceutical based on gene expression across your population cohort.

  • OpenArray Pharmacogenetic panels
    Deliver a sample-to-answer workflow that allows you to introduce pharmacogenomic testing into your laboratory with ease.
  • Pharmacoscan microarrays
    Allow clinical researchers to gain valuable insight into an individual’s ability to process drugs known to be clinically actionable based upon high, moderate, low, and preliminary scientific evidence.


Manufacturing

Production-quality-control-pod

Production quality control

Expand opportunities for advancements in quality control with genetic studies on microbial and residual vector impurities and unintended cell line proliferation.

16S gene sequencing

Confirm effective exclusion of microbes from your biopharmaceutical sample preparations.

  • MicroSeq solution
    Combines the benefits of PCR and DNA sequencing technologies to enable highly accurate results.
  • Sanger sequencing
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 

Mycoplasma detection

Confirm effective exclusion of mycoplasma from cell cultures for your biopharmaceutical production research.

  • TaqMan mycoplasma detection assays
    Designed to detect virtually any gene transcript, with more than 2.8 million predesigned assays
  • TaqPath qPCR master mixes
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets. 
  • Custom fragment analysis panels
    Analysis of DNA fragments enables a variety of applications, from cell line authentication to detection of aneuploidy. 

Targeted organism detection

Identify potential contaminating microbial strains in cell cultures for biopharmaceutical production research.

  • TaqMan genotyping  assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • Custom TaqMan assays
    The custom version of our predesigned real-time PCR 5' nuclease TaqMan assays for relative quantification of RNA expression. 
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples.

Sequence detection

Identify residual plasmid DNA in your biopharmaceutical preparations for gene therapy, cell therapy, and vaccine production research.

  • Sanger sequencing reagents
    We provide optimized, streamlined kits to help you prepare samples for Sanger sequencing and fragment analysis applications
  • Custom TaqMan assays
    The custom version of our predesigned real-time PCR 5' nuclease TaqMan assays for relative quantification of RNA expression. 
  • TaqPath qPCR master mixes
    These qPCR arrays are ideal for gene expression profiling and verification applications that require the analysis of tens to thousands of targets. 

Quantitative dPCR

Quantify precise viral vector titers in your cell cultures to ensure the correct concentration of your biopharmaceutical gene and cell therapy research.

  • Custom TaqMan dPCR assays
    A powerful yet easy-to-use digital PCR experience through its unique Microfluidic Array Plate (MAP) technology.

STR matching

Verify the genetic authenticity of your cultured and stored cells and tissues with confidence.

  • Identifiler CLA kits
    Optimized to analyze 16 highly variant human STRs over a wide range of purified gDNA preparations 
  • Globalfiler CLA kits
    Allows 6-dye analysis of 24 loci, 16 of which are included in the Identifiler kits.

Expression system sequence integrity

Verify your isolated RNA sequences for integrity and purity for Northern analysis, cDNA library construction, and microarray analysis.

Antibiotic-drug-resistance-research-pod

Antibiotic and drug resistance research

Capture possible genetic drivers of antibiotic and drug resistance.  

Genotypic sequence drift

Explore changing frequencies of genetic variants in your cultured and stored cells and tissues to identify potential genes associated with resistance to your biopharmaceutical.

  • Sanger sequencing candidate loci
    Study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases. 

Targeted locus screening

Track and characterize changing frequencies in biomarkers associated with responses to your biopharmaceutical.

  • Custom TaqMan genotyping assays
    Help you detect and distinguish SNPs accurately and efficiently, so you can better understand their associations and roles in gene function and disease.
  • TaqPath ProAmp Master Mix
    High-performing, high-throughput master mixes for genotyping and copy number variation (CNV) quantitation, including inhibited samples.


Resources

covid-image-webinar

Biomarker analyses of post-COVID-19 neurological complications

In this webinar, Dr. Lynn Pulliam discusses her study that suggests possible neurological impacts of peripheral and neuroinflammation after COVID-19 infection.

Her study also reveals distinctions in possible neural damage associated with severity of COVID-19 infection.

View webinar ›
sanger-sequencing-quality-control

Sanger sequencing for quality control in AAV vector production

The use of AAV-mediated gene transfer is growing rapidly in basic and translational research as well as clinical gene therapy trials.

In this blog, we highlight the importance of quality control in recombinant AAV (rAAV) vector preparations and how DNA sequencing is key to qualitative and quantitative characterization of the product.

Read blog post ›
capillary-electrophoresis-drug-development

Wait, what? The role of capillary electrophoresis in drug development

Discover how capillary electrophoresis can be used to rapidly screen drugs and determine their mode of action when used in conjunction with in vitro assays.

High-throughput and multiplexing capabilities can be implemented to analyze potentially hundreds of samples in one plate within a few hours.

Read blog post ›
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Support and instrument expertise specific to your needs

We support you with superior services, remote tools, training, and OEM expertise we’ve spent over 35 years curating.

By getting the most out of your Applied Biosystems, Invitrogen, and Ion Torrent instruments and applications, you can keep your focus where it needs to be: making a positive impact for generations to come.

Download flyer ›
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