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Advancing your DNA discoveries |
In your pursuit to advance science, every experiment matters. Every scientific advancement and product innovation since the discovery of the structure of DNA, has brought us here today.
Advance your discoveries in DNA science with fast, accurate results with innovative products across the Molecular Biology workflow.
DNA and RNA isolation
Long before we learned the structure of DNA, it was first isolated in 1869. From harsh organics to the development of the first uniform spherical polystyrene beads in 1976, sample purification has continued to evolve.
 | KingFisher Automated Purification InstrumentKingFisher purification instruments automate the extraction and purification of DNA, RNA, proteins, and cells. Save valuable time by removing the manual processing steps that come with organic and column-based isolation methods. The optimized magnetic bead technology offers an efficient way to prep, enabling you to focus on the research ahead. Prepare for the future now with up to 60% off KingFisher instrument, kit, and plastics bundled solutions (limited time only, USA and Canada only). Why should you automate? Watch this video now to see the benefits |
cDNA synthesis
Though scientists believe RNA is an older molecule, it was not until 1956 that the RNA structure was identified. Reverse transcription, the generation of complementary DNA from an RNA template, used to take over an hour with unpredictable yields. Now cDNA synthesis can be done in 10 mins with more than 100x sensitivity.
 | SuperScript IV Reverse TranscriptaseEngineered to deliver superior performance even with challenging RNA samples. You can get up to 100X higher cDNA yield in as little as a 10-minute reaction. Check out how SuperScript reverse transcriptase powers RT-LAMP. Read the app note |
PCR
Amplification of DNA, or PCR, was invented in 1983 and commercialized in 1987. The invention of PCR relied on prior scientific milestones like the discovery of Taq polymerase in 1976. Early PCR experiments were often run overnight using 100 µL volumes with mineral oil to prevent condensation. Heated lids and faster ramp rates allow PCR reactions to be completed in under an hour with volumes as low as 10 µL today.
 | ProFlex PCR SystemThe Proflex PCR System fits how your work today and tomorrow with 5 interchangeable block formats; maximize your throughput or run three experiments at once. Looking for a thermal cycler for in vitro diagnostic use? Explore VeritiPro Dx |
 | Platinum DNA PolymeraseInvitrogen Platinum SuperFi II DNA Polymerase offers efficiency and simplicity in PCR applications that require high PCR accuracy, such as cloning, sequencing, and mutagenesis. |
Cloning
In 1968 the first restriction enzyme was isolated. By 1977 the first cloning vector (pBR322) was reported. Mapping restrictions sites, buffer charts and one-hour incubations were commonplace.
Now there are robust seamless cloning methodologies that don't require restriction and ligation and allow assembly of multiple DNA fragments regardless of length or end compatibility, in a highly efficient, seamless method.
 | MultiShot Competent CellsChoosing the ideal competent cells for your cloning applications and workflows is critical for the success of your experiment. To facilitate high-throughput transformation use our versatile MultiShot Competent Cells, available in three packaging formats, StripWell, FlexPlate, and TOP10 96-well plates to streamline your cloning workflow. |
Plasmid purification
In 1985 the first plasmid cloning vectors were genetically engineered. Plasmid DNA used to be isolated using cesium chloride gradients, a difficult and time-consuming process. Modern, column-based systems quickly and easily produce large quantities of purified plasmids suitable for mammalian cell transfection.
 | PureLink Expi Endotoxin-Free Plasmid PurificationPureLink Expi kits enable fast purification of endotoxin-free plasmid DNA. These column-based purification kits feature an enhanced anion exchange membrane. This isolation technology offers high yield and quality plasmid DNA in a fraction of the time as compared to other standard protocols. Expi Endotoxin-Free plasmid kits are available in maxi, mega, and giga plasmid prep sizes. |
Test plasmid
The first successful electrophoresis chamber was invented in 1938! It wasn’t until 1972 that the use of ethidium bromide advanced DNA visualization. Now with the convenience of precast agarose gels, what used to take an hour is now more safely completed in as little as 15 minutes.
 | E-Gel Power Snap Plus Electrophoresis SystemE-Gel Power Snap Plus Electrophoresis System combines the convenience of quick real-time nucleic acid analysis with high-quality visualization in both high and low-throughput E-gels. Get results in as little as 15 minutes. No need to pour buffers or your own gels—Power Snap Plus is an integrated system to run, visualize and image gels as a dry, precast bufferless system! |
 | E-Gel Precast Agarose GelsInvitrogen E-Gel Precast Agarose Gels with SYBR Safe Gel Stain are designed for safer, more convenient DNA electrophoresis—eliminating the use of age old ethidium bromide stains. |
DNA and RNA isolation
Long before we learned the structure of DNA, it was first isolated in 1869. From harsh organics to the development of the first uniform spherical polystyrene beads in 1976, sample purification has continued to evolve.
| KingFisher Automated Purification InstrumentKingFisher purification instruments automate the extraction and purification of DNA, RNA, proteins, and cells. Save valuable time by removing the manual processing steps that come with organic and column-based isolation methods. The optimized magnetic bead technology offers an efficient way to prep, enabling you to focus on the research ahead. Prepare for the future now with up to 60% off KingFisher instrument, kit, and plastics bundled solutions (limited time only, USA and Canada only). Why should you automate? Watch this video now to see the benefits |
cDNA synthesis
Though scientists believe RNA is an older molecule, it was not until 1956 that the RNA structure was identified. Reverse transcription, the generation of complementary DNA from an RNA template, used to take over an hour with unpredictable yields. Now cDNA synthesis can be done in 10 mins with more than 100x sensitivity.
| SuperScript IV Reverse TranscriptaseEngineered to deliver superior performance even with challenging RNA samples. You can get up to 100X higher cDNA yield in as little as a 10-minute reaction. Check out how SuperScript reverse transcriptase powers RT-LAMP. Read the app note |
PCR
Amplification of DNA, or PCR, was invented in 1983 and commercialized in 1987. The invention of PCR relied on prior scientific milestones like the discovery of Taq polymerase in 1976. Early PCR experiments were often run overnight using 100 µL volumes with mineral oil to prevent condensation. Heated lids and faster ramp rates allow PCR reactions to be completed in under an hour with volumes as low as 10 µL today.
| ProFlex PCR SystemThe Proflex PCR System fits how your work today and tomorrow with 5 interchangeable block formats; maximize your throughput or run three experiments at once. Looking for a thermal cycler for in vitro diagnostic use? Explore VeritiPro Dx |
| Platinum DNA PolymeraseInvitrogen Platinum SuperFi II DNA Polymerase offers efficiency and simplicity in PCR applications that require high PCR accuracy, such as cloning, sequencing, and mutagenesis. |
Cloning
In 1968 the first restriction enzyme was isolated. By 1977 the first cloning vector (pBR322) was reported. Mapping restrictions sites, buffer charts and one-hour incubations were commonplace.
Now there are robust seamless cloning methodologies that don't require restriction and ligation and allow assembly of multiple DNA fragments regardless of length or end compatibility, in a highly efficient, seamless method.
| MultiShot Competent CellsChoosing the ideal competent cells for your cloning applications and workflows is critical for the success of your experiment. To facilitate high-throughput transformation use our versatile MultiShot Competent Cells, available in three packaging formats, StripWell, FlexPlate, and TOP10 96-well plates to streamline your cloning workflow. |
Plasmid purification
In 1985 the first plasmid cloning vectors were genetically engineered. Plasmid DNA used to be isolated using cesium chloride gradients, a difficult and time-consuming process. Modern, column-based systems quickly and easily produce large quantities of purified plasmids suitable for mammalian cell transfection.
| PureLink Expi Endotoxin-Free Plasmid PurificationPureLink Expi kits enable fast purification of endotoxin-free plasmid DNA. These column-based purification kits feature an enhanced anion exchange membrane. This isolation technology offers high yield and quality plasmid DNA in a fraction of the time as compared to other standard protocols. Expi Endotoxin-Free plasmid kits are available in maxi, mega, and giga plasmid prep sizes. |
Test plasmid
The first successful electrophoresis chamber was invented in 1938! It wasn’t until 1972 that the use of ethidium bromide advanced DNA visualization. Now with the convenience of precast agarose gels, what used to take an hour is now more safely completed in as little as 15 minutes.
| E-Gel Power Snap Plus Electrophoresis SystemE-Gel Power Snap Plus Electrophoresis System combines the convenience of quick real-time nucleic acid analysis with high-quality visualization in both high and low-throughput E-gels. Get results in as little as 15 minutes. No need to pour buffers or your own gels—Power Snap Plus is an integrated system to run, visualize and image gels as a dry, precast bufferless system! |
| E-Gel Precast Agarose GelsInvitrogen E-Gel Precast Agarose Gels with SYBR Safe Gel Stain are designed for safer, more convenient DNA electrophoresis—eliminating the use of age old ethidium bromide stains. |
Gene synthesis technologies make it possible to get your custom cloned gene without the benchwork. |
 | Move away from manual and time consuming sample prep Save up to 60% on KingFisher automated purification instruments, reagents, and plastics for all your DNA, RNA, protein and cell extractions for your downstream research needs. |
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Featured resources
Explore the workflow innovations and resources that are fueling faster discovery over the years. Review the milestones.
Molecular Biology Personality Quiz
When working in the lab, understanding your unique research strengths can help you work more efficiently in the lab and help drive your innovations forward.
DNA & RNA Learning Center
Read scientific articles, watch webinars and videos about innovations in lab automation, nucleic acid extraction techniques, and scientific research.
Speaking of Mol Bio
In this podcast series Speaking of Mol Bio we have bold conversations that inspire confidence in the future of molecular biology to tackle complex, real-world problems.
 | Download our free molecular biology handbook and explore other education resources from the School of Molecular Biology today. |
For Research Use Only. Not for use in diagnostic procedures.
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