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Cytogenetic/Copy number analysis with microarrays

Microarrays are an ideal platform for copy number variation (CNV) analysis and molecular cytogenetic research. Our microarray-based assays are a reliable genome-wide approach for high-resolution DNA copy number analysis to detect gains, losses, loss of heterozygosity (LOH)/absence of heterozygosity (AOH), copy-neutral loss of heterozygosity (cnLOH), regions identical-by-descent, and mosaicism. Quickly and easily identify aneuploidies, micro-deletions, micro-duplications, as well as other types of chromosomal aberrations across the genome.

Find out more about cytogenetic/copy number analysis with Applied Biosystems CytoScan HD Suite microarray.


CytoScan HD Suite is the unrivalled standard in cytogenetics research and delivers with:

Exceptional performance-coverage without compromise
CytoScan HD Suite provides the broadest coverage and highest performance for detecting chromosomal aberrations. CytoScan HD Suite has greater than 99% sensitivity and can reliably detect 25-50kb copy number changes across the genome at high specificity with single-nucleotide polymorphism (SNP) allelic corroboration.

With more than 2.6 million copy number markers, CytoScan HD Suite covers all OMIM and RefSeq genes.

High-density SNPs with >99% genotype accuracy
Enables low-level mosaicism visualisation, absence of heterozygosity (AOH) and acquired UPD (aUPD) detection, copy number change confirmation, triploidy detection, and more.

The broadest range of sample types supported - including POC FFPE
CytoScan HD Suite supports several different sample types for cancer and constitutional cytogenetic research analysis, including blood, bone marrow, buccal, saliva, fresh and frozen tissues, DBS cards, direct/cultured cells, amniocytes, and products of conception (POC), fresh and formalin-fixed, paraffin-embedded non-archived samples among others.

Robust manual or automated assay workflows-DNA to result in less than three days
CytoScan HD Solution has been optimised to save laboratory time, money and resources. The CytoScan protocol can be accomplished in 2.5 days with just 7 hours of hands-on time.

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Chromosome Analysis Suite (ChAS)

Chromosome Analysis Suite is a software offering intuitive and flexible workflow for accurate analysis tailored for cytogenetics.

ChAS was developed with input from leading experts and is customised for copy number and cytogenetics research analysis and reporting. ChAS enables you to view and summarise chromosomal aberrations across the genome. Chromosomal aberrations may include copy number gain or loss, mosaicism, or loss/absence of heterozygosity (LOH/AOH).

Try it for yourself.

Download ChAS 3.3  Learn more

B-Allele Frequency (BAF) display.

Histogram track view.

For Research Use Only. Not for use in diagnostic procedures.