m/z News – rise above the noise

Welcome to m/z News

We love mass spectrometry. This newsletter will update you on the latest happenings in this exciting field. Whether you’re analyzing proteins in plasma, PCBs in polar bears, or pesticides in pumpkins — we are bringing it all.

If you have a topical MS article to share, please send details to mzNews@thermofisher.com.

Receive m/z News via email


Topics in edition 1, March 2019


The Rise of Tandem Quadrupole Mass Spectrometry

Bob Finnigan is something of a visionary in analytical chemistry; After dominating the market with his GC-MS products in the early 1970s, he then created the first commercial tandem quadrupole MS/MS systems shortly after their invention forty years ago. Then he also developed the first commercial LC-MS system. Read about the development timeline and course of events that lead to Finnigan and Thermo Fisher Scientific being part of forty years of LC-MS/MS innovation in this new blog.

Top

Symphogen – Accelerating the drug pipeline with Native Mass Spectrometry

Symphogen – Accelerating the drug pipeline with Native Mass Spectrometry

Danish oncology-focused biopharmaceutical company, Symphogen, develop complex monoclonal antibody mixtures containing two-six mAbs to treat cancer.

This complexity presents an enormous analytical challenge that required new perspectives and workflows to solve. Learn how Symphogen are using charge variant separations combined with native mass spectrometry to overcome and simplify their analytical challenges, and develop drugs faster.

Top

Get answers fast

Get answers fast

Stuck on a question you have around your MS instrument or software? New to our MS and want to consume general tips and tricks as you get started or need to troubleshoot? Introducing our Mass Spectrometry Support Centers – a one stop digital resource for your quick success with Thermo Scientific instruments and software. Access a host of technical resources and FAQs that help minimize downtime in your laboratory.

Get support ›

Top

How massive is the MS business?

How massive is the MS business?

Frost & Sullivan estimate that the global market for laboratory mass spectrometers is almost 45,000 units per year ($3.7B, 2018). That is more units each year than all of the world’s 26,368 universities and 16,500 large hospitals combined.

Top

Addressing the “Identity Crisis” in Small Molecule Compound Identification

Addressing the “Identity Crisis” in Small Molecule Compound Identification

Combine industry-leading mass analyzer technology for small molecule analysis with an intelligent MSn data acquisition strategy, to collect more meaningful data. By capturing more low-abundance analytes and leveraging streamlined data analysis and mass spectral prediction tools, the Thermo Scientific Orbitrap ID-X Tribrid Mass Spectrometer system's intuitive, automated workflow accelerates results.

Sample to structure; pathways to insight

Sample to structure; pathways to insight

Full scan MS systems produce large amounts of data.  We introduced the Thermo Scientific Compound Discoverer 3.0 or greater software to efficiently extract high-confidence understandings with a full suite of tools to address your small molecule data analysis challenges. Streamline unknown identification, determination of real differences between samples, and elucidation of biological pathways.

Top

Achieve a new level of intact protein structural insight

Detailed structural insights enhance our understanding of protein function, disease mechanisms, potential drug targets and biotherapeutic compounds. Sophisticated mass advancements in the new Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometer give performance at high m/z to resolve small mass differences to characterize intact biomolecular assemblies, even viruses, and reveal previously unknown sub stoichiometric details.

Top

Mass Spectrometry Milestones wall posters

Mass Spectrometry Milestones wall posters

Hard to imagine where the science of forensics and sports doping would be without LC-MS. Request a free milestones poster for your Forensics or Sports Doping laboratory:

Top

Social Hero: Professor Kermit Murray

At m/z News we want to share with you leaders in mass spectrometry who shape the MS dialogue through social media.This edition we recommend - Professor Kermit Murray @kermitmurray

A true master of MS lingo, Kermit K. Murray is Professor of Chemistry at Louisiana State University, and is instrumental in the campaign for standardized MS nomenclature. He was elected an IUPAC Fellow for development of mass spectrometry terminology and on-line resources. At m/z News we love following Kermit on Twitter as he shares the latest publications from numerous MS journals.

Top

Addressing the “Identity Crisis” in Small Molecule Compound Identification

Addressing the “Identity Crisis” in Small Molecule Compound Identification

In this webinar, we will describe a fundamental new approach to untargeted small molecule analysis involving optimized mass spectrometers, powerful new data acquisition strategies, and an arsenal of new software tools to translate high quality Orbitrap mass spectra into more, confidently-assigned small molecule structures.

Watch now ›

Peptide data modeling studies using the Thermo Scientific Q Exactive HF-X Orbitrap MS

Peptide data modeling studies using the Thermo Scientific Q Exactive HF-X Orbitrap MS

This presentation provides step-by-step guide for construction of peptide retention library using 2D LC-MS/MS (high pH RP – low pH RP separation scheme, Q Exactive HF-X Hybrid Quadrupole-Orbitrap Mass Spectrometer) analysis of whole cell tryptic digests.

Watch now ›

Top