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The nuclear pore complex (NPC) serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. Each NPC consists of ~1,000 protein subunits, termed nucleoporins, and totals to a molecular mass of ~110 Mda. NPCs maintain the integrity of the nuclear compartment by preventing macromolecules from freely diffusing in or out of the nucleus. (Annu Rev Biochem, 2019. PMID 30883195)
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