BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.
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3'(2'); 3'(2'),5'-bisphosphate nucleotidase 1; 4-phosphatase; 5'-bisphosphate nucleotidase 1; Bisphosphate 3'-nucleotidase 1; BPntase; epididymis luminal protein 20; PAP-inositol 1,4-phosphatase; PAP-inositol-1; PAP-inositol-1,4-phosphatase; PIP; testicular tissue protein Li 29