DR3/TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of DR3/TNFRSF25 in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
InvitrogenDR3 Antibody (11H6L9), ABfinity™ Rabbit Monoclonal DR3 Antibody (11H6L9), ABfinity™ Rabbit Monoclonal
Cat # 702277
InvitrogenDR3 Antibody (11HCLC), ABfinity™ Rabbit Oligoclonal DR3 Antibody (11HCLC), ABfinity™ Rabbit Oligoclonal
Cat # 711309
InvitrogenDR3 Monoclonal Antibody (JD3), Biotin, eBioscience™ DR3 Monoclonal Antibody (JD3), Biotin, eBioscience™
Cat # 13-6603-82
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