Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.
ECE-2; EEF1AKMT4-ECE2 readthrough transcript protein; Endothelin-converting enzyme 2; Endothelin-converting enzyme 2 region; KIAA0604; Methyltransferase-like region; MGC2408