FGFb (fibroblast growth factor basic) or FGF2, belongs to the fibroblast growth factor (FGF) family, and interact with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGFb exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4.
Basic fibroblast growth factor; basic fibroblast growth factor bFGF; BFGF; FGF-2; FGFB; Fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; prostatropin
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