The Hox proteins are a family of transcription factors that play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. Hox proteins are involved in controlling axial patterning, leukemias and hereditary malformations. HoxD12 (homeobox D12), also known as HOX4H, is a 275 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. One of several members of the homeobox superfamily, HoxD12 functions as a sequencespecific transcription factor that is important for the correct positioning of developing limb buds on the anterior-posterior axis.
homeo box D12; homeobox D12; Homeobox protein Hox-4.7; Homeobox protein Hox-4H; Homeobox protein Hox-5.6; Homeobox protein Hox-D12; Hox-4.7 mouse homolog of; Hox-4.7, mouse, homolog of; HOX4H