Histones are basic nuclear proteins that are responsible for the structure of eukaryotic chromosomal fiber. H2AX is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle. In eukaryotes DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX. The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs. The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner.
H2A histone family, member X; H2A/X; H2AX; H2AX histone; histone 5 protein 2ax; Histone H2A.X; Histone H2AX
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