Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon- and Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
IFN-alpha/beta receptor 1; IFN-alpha/betaR; IFN-R-1; INF-a receptor; Interferon alpha/beta receptor 1; interferon-alpha/beta receptor 1; Type I interferon receptor 1
Please enter the information below and press OK to send your cart to Core Services for purchase.