Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells.
GSF5; IgSF5; immunoglobulin superfamily 5 like; Immunoglobulin superfamily member 5; immunoglobulin superfamily, member 5; JAM-4; JAM4; Junctional adhesion molecule 4