IL-12 (Interleukin 12) is produced primarily by macrophages, neutrophils, and dendritic cells. It is a disulphide linked heterodimeric cytokine with a 40 KDa subunit (p40) and a 35 KDa subunit. IL-12 is a regulatory cytokine important for mediating cellular immune responses. It helps in induction of cytotoxic activities, proliferation, and Th1 cell development. Human and mouse IL12 p40 share about 70% amino acid sequence homology.
CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; IL-12B; IL12; IL12, subunit p40; IL12P40; interleukin 12; interleukin 12, p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; Interleukin-12 subunit beta; natural killer cell stimulatory factor; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF2; subunit p40
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