NKAT (NK-associated transcripts) gene products, known as killer immuno-globulin-like receptors or KIRs, downregulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. This family of receptors is characterized by an extracellular region with two to three immunoglobulin-superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM). KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I/VxYxxL/V) known as an ITIM (immunoreceptor tyrosine-based inhibitory motif). The human inhibitory human killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3), also referred to as CD158b, is an inhibitory receptor that is specific for the human MHC class I molecule HLA-Cw3 and related alleles.
CD158 antigen-like family member B2; CD158b2; Killer cell immunoglobulin-like receptor 2DL3; killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 3; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; killer Ig-like inhibitory receptor; Killer inhibitory receptor cl 2-3; KIR-023GB; MHC class I NK cell receptor; natural killer associated transcript 2; natural killer cell inhibitory receptor KIR2DL3; Natural killer-associated transcript 2; NK-receptor; NKAT-2; NKAT2a; NKAT2b; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I specific NK receptor; p58.2 MHC class-I-specific NK receptor