Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-S5 (mitochondrial ribosomal protein S5), alternatively known as S5mt, is a 430 amino acid mitochondrial protein belonging to the ribosomal protein S5P family. A component of the 28S subunit, MRP-S5 contains one S5 DRBM domain and exists as two alternatively spliced isoforms. The gene encoding MRP-S5 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstrom syndrome.
28S ribosomal protein S5, mitochondrial; mitochondrial 28S ribosomal protein S5; Mitochondrial small ribosomal subunit protein uS5m; MRP-S5; S5mt
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