Mucins (MUCs) are heavily glycosylated glycoproteins that are synthesized either as membrane-bound or secreted proteins. Mucins are noteworthy because they have an aberrant expression profile in various malignancies. Mucins normally play a protective role for epithelial tissues and are expressed in the gastrointestinal, respiratory, and genito-urinary tracts. Mucins may also be involved in the renewal and differentiation of the epithelium, and the modulation of cell adhesion and cell signaling. MUC5B is thought to play a vital role in maintaining oral health, and may also be involved in respiratory and oral disease.2 MUC5B expression has been studied in gastric carcinoma as well as chronic obstructive pulmonary disease.
Cervical mucin; cervical mucin MUC5B; High molecular weight salivary mucin MG1; MUC-5B; MUC5; MUC5B; mucin 5, subtype B, tracheobronchial; Mucin-5 subtype B; Mucin-5 subtype B, tracheobronchial; Mucin-5B; Sublingual gland mucin; tracheobronchial