Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.
coagulation factor II (thrombin) receptor-like 2; Coagulation factor II receptor-like 2; Coagulation factor II receptor-like 2 (protease-actovated receptor 3); F2RL2; PAR-3; PAR3; Protease-activated receptor 3; Proteinase-activated receptor 3; proteinase-activated receptor-3; Thrombin receptor-like 2