The protein encoded by this gene is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. PDGFC has potent mitogen and chemoattractant for cells of mesenchymal origin, and is required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Additionally, it is required for normal skin morphogenesis during embryonic development. PDGFC plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. It plays an important role in angiogenesis and blood vessel development, and is also involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
Fallotein; PDGF-C; PDGFC latent form; PDGFC receptor-binding form; Platelet-derived growth factor C; Platelet-derived growth factor C, latent form; Platelet-derived growth factor C, receptor-binding form; SCDGF; secretory growth factor-like protein; Spinal cord-derived growth factor; VEGF-E