The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; NYD-SP27; Phosphoinositide phospholipase C-zeta-1; phospholipase C, zeta 1; Phospholipase C-zeta-1; PI-phospholipase C zeta 1; PLC-zeta-1; PLCZ1; PLCzeta; testicular tissue protein Li 145; Testis-development protein NYD-SP27; testis-development related NYD-SP27