PRSS3 encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. PRSS3 is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.
4 (trypsin 4; Brain trypsinogen; brain); Mesotrypsin; Mesotrypsinogen; MTG; pancreatic trypsinogen III; protease; protease, serine, 4 (trypsin 4, brain); PRSS4; serine; Serine protease 3; Serine protease 4; TRY3; TRY4; Trypsin III; Trypsin IV; Trypsin-3; trypsinogen 4; trypsinogen 5; trypsinogen IV