The protein encoded by this gene is a member of the protein tyrosine phosphatase family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
KIAA0283; protein tyrosine phosphatase, receptor type, T; PTPRT; R-PTP-T; receptor protein tyrosine phosphatase; Receptor-type tyrosine-protein phosphatase rho; Receptor-type tyrosine-protein phosphatase T; RP5-1121H13.2; RPTP-rho; RPTPrho