Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. Belongs to the TFIID complex which is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF10 via the histone fold. Interacts with TAF13, TBP, SAP130 and GCN5L2. Interacts with TBPL2.
140 kDa TATA box-binding protein-associated factor; 140kDa; RNA polymerase II transcription factor; RNA polymerase II transcription factor TAFII140; TAF(II)140; TAF140; TAF3 RNA polymerase II; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa; TAFII-140; TAFII140; TATA box binding protein (TBP)-associated factor; TATA box binding protein associated factor 3; TBP-associated factor 3; TFIID subunit; Transcription initiation factor TFIID 140 kDa subunit; Transcription initiation factor TFIID subunit 3