USP6 is a deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. It catalyzes its own deubiquitination. In vitro, isoform2, but not isoform3, shows deubiquitinating activity. USP6 promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. It is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Deubiquitinating enzyme 6; hyperpolymorphic gene 1; Proto-oncogene TRE-2; TBC1D3 and USP32 fusion; Ubiquitin carboxyl-terminal hydrolase 6; ubiquitin specific peptidase 6 (Tre-2 oncogene); ubiquitin specific protease 6 (Tre-2 oncogene); Ubiquitin thioesterase 6; ubiquitin thiolesterase 6; ubiquitin-specific protease USP6; Ubiquitin-specific-processing protease 6